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Showing 1–2 of 2 results
Advanced filters: Author: Luke Buerer Clear advanced filters

  • Dbr1 exhibits debranching specificity and effect on splicing. Here the authors combine co-immunoprecipitation, RNA binding and lariat analysis and suggest a role for Dbr1 interactor AQR in intron recycling. Dbr1 depletion leads to increased dwell time of spliceosome on excised lariats.

    • Luke Buerer
    • Nathaniel E. Clark
    • William G. Fairbrother
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Splicing is regulated by cis-acting elements in pre-mRNAs such as exonic or intronic splicing enhancers and silencers. Here the authors show that exonic splicing enhancers are enriched in exons compared to introns due to mutational bias coupled with purifying selection on the protein code.

    • Stephen Rong
    • Luke Buerer
    • William G. Fairbrother
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10