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Communications Biology (2)

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Sequence-structure-function characterization of the emerging tetracycline destructase family of antibiotic resistance enzymes

Deep investigation of the sequence-structure-function landscape of the tetracycline destructase family of antibiotic resistance enzymes identifies new enzymes, and amino acid spositions essential to activity.

Kevin S. Blake
Hirdesh Kumar
Gautam Dantas
ResearchOpen Access16 Mar 2024
Communications Biology

Volume: 7, P: 1-16
Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family

A comprehensive functional and structural study of the Antibiotic_NAT family of aminoglycoside acetyltransferases provides new insight into the molecular mechanisms underlying resistance to existing and emerging aminoglycoside antibiotics.

Peter J. Stogios
Emily Bordeleau
Alexei Savchenko
ResearchOpen Access25 Mar 2022
Communications Biology

Volume: 5, P: 1-12

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Sequence-structure-function characterization of the emerging tetracycline destructase family of antibiotic resistance enzymes

Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family

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