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Showing 1–4 of 4 results
Advanced filters: Author: Luke Frankiw Clear advanced filters

  • Detailed understanding of how cancer cells transition from a drug sensitive to a tolerant state is lacking. Here, using single cell proteomic and metabolic data the authors uncover that isogenic BRAF mutant melanoma cells can take two distinct paths to become tolerant to BRAF inhibition.

    • Yapeng Su
    • Melissa E. Ko
    • James R. Heath
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Although Capicua (Cic), a transcriptional repressor, is linked to cancer, little is known about its function in the non-diseased brain. Here, authors show that Cic is strongly expressed in astrocytic and neuronal lineage cells during development and regulates proliferation and lineage selection via de-repression of Ets transcription factors.

    • Shiekh Tanveer Ahmad
    • Alexandra D. Rogers
    • Jennifer A. Chan
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • The identification of suitable tumour-specific antigens, which can be targeted by vaccine-based or T cell-based immunotherapies, is challenging. This Review explores the potential of alternative splicing to generate unique tumour antigens and discusses methods for their identification.

    • Luke Frankiw
    • David Baltimore
    • Guideng Li
    Reviews
    Nature Reviews Immunology
    Volume: 19, P: 675-687