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Showing 1–10 of 10 results
Advanced filters: Author: Luke L. McGoldrick Clear advanced filters

  • Here, cryo-electron microscopy structures reveal how the chemokine receptor CXCR4 oligomerizes and how it is regulated by its physiological ligand CXCL12, the small-molecule drug AMD3100 and the monoclonal antibody REGN7663.

    • Kei Saotome
    • Luke L. McGoldrick
    • Matthew C. Franklin
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 32, P: 315-325

  • Transient receptor potential (TRP) channels are ubiquitous occurring cation-selective sensory ion channels that respond to various stimuli. Here the authors characterize crTRP1 from the alga Chlamydomonas reinhardtii, present its 3.5 Å cryo-EM structure and show that crTRP1 opens in response to increased temperature and is positively regulated by the membrane lipid PIP2.

    • Luke L. McGoldrick
    • Appu K. Singh
    • Alexander I. Sobolevsky
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • γδTCRs detect and initiate immune responses to various antigens. Here, Hoque et al. report cryoEM structures of two γδTCRs bound by Fabs, revealing their assembly with CD3 signaling components and clonotype-dependent propensity for dimerization.

    • Mohammed Hoque
    • John Benji Grigg
    • Kei Saotome
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • The cryo-electron microscopy structure of the calcium channel TRPV6 in its open and closed states demonstrates a novel gating mechanism involving an alanine hinge.

    • Luke L. McGoldrick
    • Appu K. Singh
    • Alexander I. Sobolevsky
    Research
    Nature
    Volume: 553, P: 233-237

  • The transient receptor potential channel TRPV6 mediates calcium uptake in epithelia and its expression is increased in several cancer types. Here, authors present structures of TRPV6 bound to 2-APB, a TRPV6 inhibitor, and show that 2-APB induces TRPV6 channel closure by modulating protein–lipid interactions.

    • Appu K. Singh
    • Kei Saotome
    • Alexander I. Sobolevsky
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • Cryo-EM structures of mouse TRPV3 in open, closed and intermediate states, obtained by incubation of the protein samples at different temperatures immediately prior to freezing, offer insight into conformational changes induced by heat in TRPV3.

    • Appu K. Singh
    • Luke L. McGoldrick
    • Alexander I. Sobolevsky
    Research
    Nature Structural & Molecular Biology
    Volume: 26, P: 994-998

  • Mammalian sperm must respond to a variety of cues, and dynamic regulation of ion signalling is, therefore, essential for sperm cells to adapt to their environment. In this Review, the authors describe the ion channels and membrane receptors controlling sperm activity, in particular the principal Ca2+-selective plasma membrane ion channel CatSper, and consider how sperm ion channels and membrane receptors are attractive targets for therapeutics and how these signalling processes might have implications for assisted reproductive technologies.

    • Huafeng Wang
    • Luke L. McGoldrick
    • Jean-Ju Chung
    Reviews
    Nature Reviews Urology
    Volume: 18, P: 46-66