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Showing 1–4 of 4 results
Advanced filters: Author: Lumen Chao Clear advanced filters

  • Uterine fluid supports early embryo development. This study reveals maternal high-fat diet alters tsRNA/rsRNA profiles in uterine fluid, leading to abnormal embryonic metabolism and offspring disorders, demonstrating a novel mode of RNA-mediated communication.

    • Shijia Pan
    • Liwen Zhang
    • Ying Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • In two independent studies, Song et al. and Jiang, Dalgarno et al. present computational frameworks, perturbation-response score and Mixscale, respectively, to determine individual cellular variation in response to perturbation.

    • Bicna Song
    • Dingyu Liu
    • Wei Li
    ResearchOpen Access
    Nature Cell Biology
    Volume: 27, P: 493-504

  • Cas13 can intrinsically target host RNA in mammalian cells through previously unrecognized mechanisms without the involvement of a CRISPR RNA, and host genes involved in viral processes can constrain the lentiviral delivery and expression of Cas13.

    • Zexu Li
    • Zihan Li
    • Teng Fei
    Research
    Nature Biomedical Engineering
    Volume: 8, P: 177-192

  • Application of CRISPR-Cas13d is limited by the inability to predict on- and off-targets. Here the authors perform CRISPR-Cas13d proliferation screens followed by modeling of Cas13d on- and off-targets; they design a deep learning model, DeepCas13, to predict the on-target activity of a gRNA.

    • Xiaolong Cheng
    • Zexu Li
    • Wei Li
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14