Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

View all journals
Search
Log in

nature
search

Search

Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Nature (3)
Nature Structural & Molecular Biology (1)

Choose more journals

Article type Check one or more article types to show results from those article types only.

Research (3)
Amendments and Corrections (1)

Subject Check one or more subjects to show results from those subjects only.

Biochemistry
Biological techniques
Biophysics
Microbiology
Molecular biology
Structural biology

Date Choose a date option to show results from those dates only.

Today
Last 7 days
Last 30 days
Last 12 months
Last 2 years
Last 5 years

Custom date range

Clear all filters

Sort by:

Relevance

Date published (new to old)

Date published (old to new)

Showing 1–4 of 4 results

Advanced filters: Author: Luuk Loeff Clear advanced filters

Publisher Correction: R-loop formation and conformational activation mechanisms of Cas9

Martin Pacesa
Luuk Loeff
Martin Jinek
Amendments and CorrectionsOpen Access30 Oct 2023
Nature

Volume: 623, P: E10
Mechanistic basis for PYROXD1-mediated protection of the human tRNA ligase complex against oxidative inactivation

By using cryo-EM and biochemical assays, Loeff et al. reveal the mechanistic basis for the protective function of the oxidoreductase PYROXD1 that maintains the activity of the tRNA ligase complex under aerobic conditions.

Luuk Loeff
Alena Kroupova
Martin Jinek
ResearchOpen Access11 Mar 2025
Nature Structural & Molecular Biology

Volume: 32, P: 1205-1212
R-loop formation and conformational activation mechanisms of Cas9

Cryo-electron microscopy structures of Streptococcus pyogenes Cas9 in multiple DNA-bound states provide insights on the mechanism of Cas9 activation by target DNA.

Martin Pacesa
Luuk Loeff
Martin Jinek
ResearchOpen Access24 Aug 2022
Nature

Volume: 609, P: 191-196
Selective loading and processing of prespacers for precise CRISPR adaptation

Cas1–Cas2 selects precursor prespacers from DNA fragments in a length- and PAM-sequence-dependent manner, and these precursors are trimmed by DnaQ exonucleases to enable integration into the CRISPR locus in the correct orientation.

Sungchul Kim
Luuk Loeff
Chirlmin Joo
Research19 Feb 2020
Nature

Volume: 579, P: 141-145