Chemotherapy-induced cytosolic DNA has been shown to activate the cGAS-STING pathway. Here, the authors demonstrate that the efficacy of low-dose doxorubicin to elicit a STING-mediated anti-tumour immune response can be enhanced by liposomal-loading with indocyanine green, resulting in ultrasound-activatable enhanced nuclear doxorubicin localisation and release of mitochondrial DNA.
- Chaoyu Wang
- Ruoshi Zhang
- Rui Kuai
