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Showing 1–3 of 3 results
Advanced filters: Author: Lydia Herzel Clear advanced filters

  • The U6 snRNA internal stem loop (ISL) forms the catalytic core of the spliceosome. Here, the authors reveal a hierarchal modification pathway for the U6 ISL, and highlight the independent and interdependent importance of modified nucleotides in the ISL for snRNP maturation and optimal pre-mRNA splicing.

    • Nicole Kleiber
    • Jonny Petrosyan
    • Katherine E. Bohnsack
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-24

  • Methodological advances have enabled discoveries of RNA polymerase interactions with RNA processing machineries, such as the splicing and 3′-end cleavage machineries. This Review discusses the roles of these interactions in gene regulation and eukaryotic cellular stress responses, and highlights parallels between co-transcriptional RNA processing in eukaryotes and prokaryotes.

    • Morgan Shine
    • Jackson Gordon
    • Karla M. Neugebauer
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 25, P: 534-554

  • Pre-mRNA splicing occurs on nascent RNA, which is attached to chromatin by RNA polymerase II. Much splicing occurs co-transcriptionally, and the spatial and temporal coordination of the two processes is tightly coordinated with other mRNA-processing events.

    • Lydia Herzel
    • Diana S. M. Ottoz
    • Karla M. Neugebauer
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 18, P: 637-650