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Showing 1–7 of 7 results
Advanced filters: Author: Lynne Chantranupong Clear advanced filters

  • A study of the proteasome — a protein-degradation complex — reveals an evolutionarily conserved pathway that acts through the protein kinase TORC1 to adjust proteasome levels in response to cellular needs. See Letter p.184

    • Lynne Chantranupong
    • David M. Sabatini
    News & Views
    Nature
    Volume: 536, P: 155-156

  • Experiments in mice provide insight into the dynamic relationship between dopamine and acetylcholine in the ventrolateral striatum and how this signalling circuit affects decision-making and behaviour.

    • Lynne Chantranupong
    • Celia C. Beron
    • Bernardo L. Sabatini
    ResearchOpen Access
    Nature
    Volume: 621, P: 577-585

  • The 3D structure of the human nutrient-sensing complex GATOR2 is resolved using cryo-electron microscopy.

    • Max L. Valenstein
    • Kacper B. Rogala
    • David M. Sabatini
    Research
    Nature
    Volume: 607, P: 610-616

  • Cryo-electron microscopy and biochemical analyses of the GATOR1 protein complex reveal that two binding modes underpin its ability to regulate Rag GTPases as a GTPase-activating protein for RAGA.

    • Kuang Shen
    • Rick K. Huang
    • David M. Sabatini
    Research
    Nature
    Volume: 556, P: 64-69

  • mTORC1 is shown to regulate a translational program that requires the rapamycin-resistant 4E-BP family of translational repressors and consists almost entirely of mRNAs containing 5′ terminal oligopyrimidine or related motifs.

    • Carson C. Thoreen
    • Lynne Chantranupong
    • David M. Sabatini
    Research
    Nature
    Volume: 485, P: 109-113

  • Structural data on the protein CASTOR1 reveal how the mTORC1 pathway senses intracellular arginine, suggesting a repurposing of an evolutionarily pre-metazoan mechanism.

    • Robert A. Saxton
    • Lynne Chantranupong
    • David M. Sabatini
    Research
    Nature
    Volume: 536, P: 229-233