The observation that tissues that undergo more stem cell divisions are less prone to develop cancer presents a paradox as these tissues should have more opportunity to accumulate cancer-causing mutations. Here, the authors present a solution to the paradox by showing how hierarchical tissues can maintain low cancer incidence by balancing mutation accumulation and the cells’ commitment to differentiation.
- Márton Demeter
- Imre Derényi
- Gergely J. Szöllősi
