Subtilase SUB1, a proteolytic enzyme required for the exit of malarial parasites from host cells, represents a promising target for anti-malarial drugs. Here, Giganti et al. report the structure of PlasmodiumSUB1 and identify an essential domain involved in calcium-dependent activation of the enzyme.
- David Giganti
- Anthony Bouillon
- Jean-Christophe Barale
