Berg Luecke et al. developed an analytical platform, CellSurfer, that enables the quantitative profiling of cell surface proteome (surfaceome) from small samples, and they apply it to primary human heart cells. The analyses revealed LSMEM2 as a surface protein specific for healthy cardiomyocytes; important surfaceome differences between primary human cardiac cells and the pluripotent stem cell derivatives; and differences in the abundance of surface proteins between human failing and non-failing cardiomyocytes.
- Linda Berg Luecke
- Matthew Waas
- Rebekah L. Gundry
