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Showing 51–76 of 76 results

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Publisher Correction: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

Shane J. F. Cronin
Corey Seehus
Josef M. Penninger
Amendments and Corrections31 Jul 2019
Nature

Volume: 572, P: E18
The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

Tetrahydrobiopterin (BH4) is an enzyme co-factor that is involved in the nervous system; it is shown here to also function in T cell activation and proliferation, with roles in autoimmunity, allergic inflammation and cancer.

Shane J. F. Cronin
Corey Seehus
Josef M. Penninger
Research07 Nov 2018
Nature

Volume: 563, P: 564-568
SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1

A-Mf Jacobs
S M Nicol
F V Fuller-Pace
Research19 Mar 2007
Oncogene

Volume: 26, P: 5866-5876
Transient expression of Bcl6 is sufficient for oncogenic function and induction of mature B-cell lymphoma

Diffuse large B-cell lymphoma is an aggressive heterogeneous tumour type with poorly understood aetiology. Here, Green et al. show that transient expression of Bcl6in haematopoietic stem cells is sufficient to induce mature B-cell lymphoma, indicating that it acts as a ‘hit-and-run’ oncogene.

Michael R. Green
Carolina Vicente-Dueñas
Isidro Sánchez-García
Research02 Jun 2014
Nature Communications

Volume: 5, P: 1-13
CTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation

Activated B cells differentiate into antibody-producing plasma cells in the germinal centre in secondary lymphoid organs. Here the authors show that this differentiation process and related transcription programs are modulated by the transcription factor CTCF, partly by suppressing the premature expression of Blimp-1.

Arantxa Pérez-García
Ester Marina-Zárate
Almudena R. Ramiro
ResearchOpen Access05 Jul 2017
Nature Communications

Volume: 8, P: 1-12
B cell–specific loss of histone 3 lysine 9 methylation in the V_H locus depends on Pax5

Kristen Johnson
David L Pflugh
Kathryn Calame
Research18 Jul 2004
Nature Immunology

Volume: 5, P: 853-861
Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5

Jagan M R Pongubala
Daniel L Northrup
Harinder Singh
Research06 Jan 2008
Nature Immunology

Volume: 9, P: 203-215
Interstitial lung disease induced by gefitinib and Toll-like receptor ligands is mediated by Fra-1

Y Takada
L Gresh
K Matsuo
Research04 Apr 2011
Oncogene

Volume: 30, P: 3821-3832
Myc drives apoptosis in PC12 cells in the absence of Max

M Wert
S Kennedy
N Hay
Research05 Jul 2001
Oncogene

Volume: 20, P: 3746-3750
Fosl1 is a transcriptional target of c-Fos during osteoclast differentiation

Koichi Matsuo
Jane M. Owens
Erwin F. Wagner
Research01 Feb 2000
Nature Genetics

Volume: 24, P: 184-187
Aberrant expression of CD19 in AML with t(8;21) involves a poised chromatin structure and PAX5

K Walter
P N Cockerill
H Tagoh
Research08 Mar 2010
Oncogene

Volume: 29, P: 2927-2937
The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers

Affinity maturation and positive selection occur in germinal centers. Turner and colleagues demonstrate that the RNA-binding protein PTBP1 serves an essential B cell–intrinsic role by regulating the abundance and alternate splicing of transcripts in germinal center B cells.

Elisa Monzón-Casanova
Michael Screen
Martin Turner
Research22 Jan 2018
Nature Immunology

Volume: 19, P: 267-278
Chromatin signatures of pluripotent cell lines

Véronique Azuara
Pascale Perry
Amanda G. Fisher
Research29 Mar 2006
Nature Cell Biology

Volume: 8, P: 532-538
Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance

Jelena Nedjic
Martin Aichinger
Ludger Klein
Research13 Aug 2008
Nature

Volume: 455, P: 396-400
Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB

Although important for early development, PU.1 is dispensable for mature B cell function, possibly owing to compensation by the related transcription factor SpiB. Here the authors show PU.1 and SpiB are collectively required for humoral immunity, through regulation of germinal centre formation and plasma cell differentiation.

Simon N. Willis
Julie Tellier
Stephen L. Nutt
ResearchOpen Access10 Nov 2017
Nature Communications

Volume: 8, P: 1-14
BCR–ABL1 induces aberrant splicing of IKAROS and lineage infidelity in pre-B lymphoblastic leukemia cells

F Klein
N Feldhahn
M Müschen
Research03 Oct 2005
Oncogene

Volume: 25, P: 1118-1124
Isolation and characterization of the human A-myb promoter: regulation by NF-Y and Sp1

V Facchinetti
R Lopa
J Golay
Research08 Aug 2000
Oncogene

Volume: 19, P: 3931-3940
Increase in AP-1 activity is a general event in thyroid cell transformation in vitro and in vivo

Sabrina Battista
Filomena de Nigris
Alfredo Fusco
Research28 Jul 1998
Oncogene

Volume: 17, P: 377-385
Variations in Jun and Fos protein expression and AP-1 activity in cycling, resting and stimulated fibroblasts

Dominique Lallemand
Giannis Spyrou
Curt M Pfarr
Research20 Feb 1997
Oncogene

Volume: 14, P: 819-830
Suppression of FOXO1 is responsible for a growth regulatory repressive transcriptional sub-signature of EWS-FLI1 in Ewing sarcoma

S Niedan
M Kauer
H Kovar
ResearchOpen Access02 Sept 2013
Oncogene

Volume: 33, P: 3927-3938
Epigenetic inactivation of paired box gene 5, a novel tumor suppressor gene, through direct upregulation of p53 is associated with prognosis in gastric cancer patients

X Li
K F Cheung
J Yu
Research21 Nov 2011
Oncogene

Volume: 31, P: 3419-3430
PU.1 cooperates with IRF4 and IRF8 to suppress pre-B-cell leukemia

S H M Pang
M Minnich
S Carotta
Research02 Mar 2016
Leukemia

Volume: 30, P: 1375-1387
Identification of mutations that cooperate with defects in B cell transcription factors to initiate leukemia

Lynn M. Heltemes-Harris
Gregory K. Hubbard
Michael A. Farrar
Research17 Sept 2021
Oncogene

Volume: 40, P: 6166-6179
Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia

M T Witkowski
L Cimmino
R A Dickins
Research06 Feb 2015
Leukemia

Volume: 29, P: 1301-1311
Incidence and diversity of PAX5 fusion genes in childhood acute lymphoblastic leukemia

K Nebral
D Denk
S Strehl
Research20 Nov 2008
Leukemia

Volume: 23, P: 134-143
Tumor suppressor IKZF1 mediates glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia

R Marke
J Havinga
B Scheijen
Correspondence29 Dec 2015
Leukemia

Volume: 30, P: 1599-1603

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