The incidence of encapsulating peritoneal sclerosis (EPS)—the most severe complication of long-term peritoneal dialysis—has increased in the past 20 years; however, no criteria exist for detecting this disease in early stages. In this Review, Korte and colleagues present the pathophysiology of EPS as a as a multiple-hit process with a central role for transforming growth factor β. They also describe the progress made in the early identification and diagnosis of EPS and potential therapeutic strategies.
- Mario R. Korte
- Denise E. Sampimon
- Raymond T. Krediet
