Nature Search

CDK12 promotes tumorigenesis but induces vulnerability to therapies inhibiting folate one-carbon metabolism in breast cancer

Finding biomarkers for targeted therapy is a promising approach to treat cancer. Here, the authors show that in breast cancer preclinical models and patients, CDK12 promotes tumourigenesis but induces selective vulnerability to therapies that target folate one-carbon metabolism.

M. G. Filippone
D. Gaglio
S. Pece
ResearchOpen Access12 May 2022
Nature Communications

Volume: 13, P: 1-19
MicroRNAs in cancer: from developmental genes in worms to their clinical application in patients

M Pichler
G A Calin
ReviewsOpen Access09 Jul 2015
British Journal of Cancer

Volume: 113, P: 569-573
GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements

Investigation of variation in three cohorts has identified multiple genetic signals associated with the pregnancy-specific liver disorder, intrahepatic cholestasis of pregnancy, giving insight into the disease which can cause preterm birth and stillbirth.

Peter H. Dixon
Adam P. Levine
Catherine Williamson
ResearchOpen Access17 Aug 2022
Nature Communications

Volume: 13, P: 1-18
Cancer cell stiffening via CoQ₁₀ and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer

The roles of CoQ10 and producing enzymes in cancer have not been well explored. Here, the authors identify that the CoQ10-biosynthetic enzyme UBIAD1 is a tumor suppressor in breast cancer. CoQ10 induced alterations in plasma membrane mechanical properties lead to increased cellular stiffness and impaired tumorigenic signaling, as well as enhanced sensitivity to ferroptosis.

Giovanni Tosi
Alessandro Paoli
Massimo M. Santoro
ResearchOpen Access18 Sept 2024
Nature Communications

Volume: 15, P: 1-24
Loss of NUMB drives aggressive bladder cancer via a RHOA/ROCK/YAP signaling axis

The transition from non-muscle-invasive bladder cancer (NMIBC) to muscle-invasive bladder cancer (MIBC) is associated with poorer patient prognosis. Here, the authors investigate NUMB loss as a driver of the NMIBC-to-MIBC transition and identify a RHOA/ROCK/YAP signaling pathway as a therapeutic vulnerability.

F. A. Tucci
R. Pennisi
S. Pece
ResearchOpen Access03 Dec 2024
Nature Communications

Volume: 15, P: 1-24
Whole-genome sequencing of patients with rare diseases in a national health system

Whole-genome sequencing and phenotype data sharing are introduced in a national health system to streamline diagnosis and to discover coding and non-coding variants that cause rare diseases.

Ernest Turro
William J. Astle
Willem H. Ouwehand
Research24 Jun 2020
Nature

Volume: 583, P: 96-102
Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Whole-genome sequencing analysis of individuals with primary immunodeficiency identifies new candidate disease-associated genes and shows how the interplay between genetic variants can explain the variable penetrance and complexity of the disease.

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Research06 May 2020
Nature

Volume: 583, P: 90-95
Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood

Idiopathic pulmonary arterial hypertension is a rare and fatal disease with a heterogeneous treatment response. Here the authors show that unsupervised machine learning of whole blood transcriptomes from 359 patients with idiopathic pulmonary arterial hypertension identifies 3 subgroups (endophenotypes) that improve risk stratification and provide new molecular insights.

Sokratis Kariotis
Emmanuel Jammeh
Richard C. Trembath
ResearchOpen Access07 Dec 2021
Nature Communications

Volume: 12, P: 1-14
Identification of rare sequence variation underlying heritable pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a rare lung disorder characterised by narrowing and obliteration of small pulmonary arteries ultimately leading to right heart failure. Here, the authors sequence whole genomes of over 1000 PAH patients and identify likely causal variants in GDF2, ATP13A3, AQP1 and SOX17.

Stefan Gräf
Matthias Haimel
Nicholas W. Morrell
ResearchOpen Access12 Apr 2018
Nature Communications

Volume: 9, P: 1-16
Phase II study of talazoparib in advanced cancers with BRCA1/2, DNA repair, and PTEN alterations

Sarina A. Piha-Paul
Chieh Tseng
Funda Meric-Bernstam
ResearchOpen Access31 Jul 2024
npj Precision Oncology

Volume: 8, P: 1-14
Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases

J-P Montani
J F Carroll
A G Dulloo
Research13 Dec 2004
International Journal of Obesity

Volume: 28, P: S58-S65
Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension

Florent Soubrier and colleagues report a genome-wide association study of pulmonary arterial hypertension. They identify a susceptibility locus near CBLN2 associated with a twofold elevated risk of developing this life-threatening disease.

Marine Germain
Mélanie Eyries
Florent Soubrier
Research17 Mar 2013
Nature Genetics

Volume: 45, P: 518-521
A gravitational-wave standard siren measurement of the Hubble constant

The astronomical event GW170817, detected in gravitational and electromagnetic waves, is used to determine the expansion rate of the Universe, which is consistent with and independent of existing measurements.

B. P. Abbott
R. Abbott
M. Serra-Ricart
Research16 Oct 2017
Nature

Volume: 551, P: 85-88
Author Correction: Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood

Sokratis Kariotis
Emmanuel Jammeh
Richard C. Trembath
Amendments and CorrectionsOpen Access25 Nov 2022
Nature Communications

Volume: 13, P: 1
Glucocorticoid resistance in T-lineage acute lymphoblastic leukaemia is associated with a proliferative metabolism

A H Beesley
M J Firth
U R Kees
ResearchOpen Access12 May 2009
British Journal of Cancer

Volume: 100, P: 1926-1936
Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Amendments and Corrections17 Jul 2020
Nature

Volume: 584, P: E2
Differences in the histological findings, phenotypic marker expressions and genetic alterations between adenocarcinoma of the gastric cardia and distal stomach

Y Tajima
K Yamazaki
M Kusano
ResearchOpen Access30 Jan 2007
British Journal of Cancer

Volume: 96, P: 631-638
Revealing structural evolution occurring from photo-initiated polymer network formation

Acomplete account of the structural evolution occurring during photopolymerisation is lacking. Here the physical changes occurring on the nanometer scale during photopolymerisation of acrylates are followed over time by FTIR, X-ray reflectometry, AFM, and GISAXS, offering insight into the mechanism by which initial composition influences the final morphology.

C. J. Brett
S. Montani
M. K. G. Johansson
ResearchOpen Access10 Jul 2020
Communications Chemistry

Volume: 3, P: 1-7
Cyclin D3 and c-MYC control glucocorticoid-induced cell cycle arrest but not apoptosis in lymphoblastic leukemia cells

M J Ausserlechner
P Obexer
R Kofler
Research24 Oct 2003
Cell Death & Differentiation

Volume: 11, P: 165-174
Sugary drinks in the pathogenesis of obesity and cardiovascular diseases

C M Brown
A G Dulloo
J-P Montani
Research15 Dec 2008
International Journal of Obesity

Volume: 32, P: S28-S34
Apoptotic cell death and cytokine dysregulation in human immunodeficiency virus infection: pivotal factors in disease progression

Mario Clerici
Apurva Sarin
Gene M Shearer
Reviews01 Dec 1997
Cell Death & Differentiation

Volume: 4, P: 699-706
Aberrant activation of p53/p66Shc-mInsc axis increases asymmetric divisions and attenuates proliferation of aged mammary stem cells

Chiara Priami
Daniela Montariello
Pier Giuseppe Pelicci
Research23 Jun 2022
Cell Death & Differentiation

Volume: 29, P: 2429-2444
Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data

James H. R. Farmery
Mike L. Smith
Andy G. Lynch
ResearchOpen Access22 Jan 2018
Scientific Reports

Volume: 8, P: 1-17
Role of temperature-independent lipoplex–cell membrane interactions in the efficiency boost of multicomponent lipoplexes

C Marchini
D Pozzi
G Caracciolo
Research11 Mar 2011
Cancer Gene Therapy

Volume: 18, P: 543-552
Prognostic and predictive value of TOPK stratified by KRAS and BRAF gene alterations in sporadic, hereditary and metastatic colorectal cancer patients

I Zlobec
F Molinari
A Lugli
ResearchOpen Access24 Nov 2009
British Journal of Cancer

Volume: 102, P: 151-161
Mesenchymal stem cells share molecular signature with mesenchymal tumor cells and favor early tumor growth in syngeneic mice

M Galiè
G Konstantinidou
A Amici
Research12 Nov 2007
Oncogene

Volume: 27, P: 2542-2551
Comprehensive validation of published immunohistochemical prognostic biomarkers of prostate cancer—what has gone wrong? A blueprint for the way forward in biomarker studies

F Huber
M Montani
G Kristiansen
ResearchOpen Access25 Nov 2014
British Journal of Cancer

Volume: 112, P: 140-148
Substrate cycling between de novo lipogenesis and lipid oxidation: a thermogenic mechanism against skeletal muscle lipotoxicity and glucolipotoxicity

A G Dulloo
M Gubler
G Solinas
Research13 Dec 2004
International Journal of Obesity

Volume: 28, P: S29-S37
Trabectedin, a drug acting on both cancer cells and the tumour microenvironment

M D’Incalci
N Badri
P Allavena
ReviewsOpen Access22 Apr 2014
British Journal of Cancer

Volume: 111, P: 646-650
Publisher Correction: Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data

James H. R. Farmery
Mike L. Smith
Andy G. Lynch
Amendments and CorrectionsOpen Access03 Sept 2018
Scientific Reports

Volume: 8, P: 1-4

Search

CDK12 promotes tumorigenesis but induces vulnerability to therapies inhibiting folate one-carbon metabolism in breast cancer

MicroRNAs in cancer: from developmental genes in worms to their clinical application in patients

GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements

Cancer cell stiffening via CoQ₁₀ and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer

Loss of NUMB drives aggressive bladder cancer via a RHOA/ROCK/YAP signaling axis

Whole-genome sequencing of patients with rare diseases in a national health system

Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood

Identification of rare sequence variation underlying heritable pulmonary arterial hypertension

Phase II study of talazoparib in advanced cancers with BRCA1/2, DNA repair, and PTEN alterations

Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases

Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension

A gravitational-wave standard siren measurement of the Hubble constant

Author Correction: Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood

Glucocorticoid resistance in T-lineage acute lymphoblastic leukaemia is associated with a proliferative metabolism

Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Differences in the histological findings, phenotypic marker expressions and genetic alterations between adenocarcinoma of the gastric cardia and distal stomach

Revealing structural evolution occurring from photo-initiated polymer network formation

Cyclin D3 and c-MYC control glucocorticoid-induced cell cycle arrest but not apoptosis in lymphoblastic leukemia cells

Sugary drinks in the pathogenesis of obesity and cardiovascular diseases

Apoptotic cell death and cytokine dysregulation in human immunodeficiency virus infection: pivotal factors in disease progression

Aberrant activation of p53/p66Shc-mInsc axis increases asymmetric divisions and attenuates proliferation of aged mammary stem cells

Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data

Role of temperature-independent lipoplex–cell membrane interactions in the efficiency boost of multicomponent lipoplexes

Prognostic and predictive value of TOPK stratified by KRAS and BRAF gene alterations in sporadic, hereditary and metastatic colorectal cancer patients

Mesenchymal stem cells share molecular signature with mesenchymal tumor cells and favor early tumor growth in syngeneic mice

Comprehensive validation of published immunohistochemical prognostic biomarkers of prostate cancer—what has gone wrong? A blueprint for the way forward in biomarker studies

Substrate cycling between de novo lipogenesis and lipid oxidation: a thermogenic mechanism against skeletal muscle lipotoxicity and glucolipotoxicity

Trabectedin, a drug acting on both cancer cells and the tumour microenvironment

Publisher Correction: Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data

Search

Quick links

Search

Filter By:

Search

Quick links