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Showing 1–50 of 53 results

Advanced filters: Author: M Tsokos Clear advanced filters

Myoglobin: an evaluation of its role as a marker of rhabdomyosarcomas

M Leader
J Patel
K Henry
Research01 Jan 1989
British Journal of Cancer

Volume: 59, P: 106-109
Retinoblastoma—origin from a primitive neuroectodermal cell?

A. P. Kyritsis
M. Tsokos
G. J. Chader
Research02 Feb 1984
Nature

Volume: 307, P: 471-473
A novel 6:10 chromosomal translocation in the murine plasmacytoma NS-1

Roger M. Perlmutter
Joan L. Klotz
Leroy Hood
Research02 Feb 1984
Nature

Volume: 307, P: 473-476
How did retinoblastoma arise?

F.A. BEEMER
C.W.M. VAN VEELEN
G.E.J. STAAL
Research30 Aug 1984
Nature

Volume: 310, P: 731
Association of IL-6 gene alleles with systemic lupus erythematosus (SLE) and with elevated IL-6 expression

M Linker-Israeli
DJ Wallace
JR Klinenberg
Research29 Sept 1999
Genes & Immunity

Volume: 1, P: 45-52
Interleukin-2 production used to detect antigenic peptide recognition by T-helper lymphocytes from asymptomatic HIV-seropositive individuals

Mario Clerici
Naomi I. Stocks
Jay A. Berzofsky
Research01 Jun 1989
Nature

Volume: 339, P: 383-385
Retinoblastoma in transgenic mice

Jolene J. Windle
Daniel M. Albert
Pamela L. Mellon
Research15 Feb 1990
Nature

Volume: 343, P: 665-669
Non-hydrophobic extracytoplasmic determinant of stop transfer in the prion protein

C. Spencer Yost
Charles D. Lopez
Vishwanath R. Lingappa
Research15 Feb 1990
Nature

Volume: 343, P: 669-672
An engineered poliovirus chimaera elicits broadly reactive HIV-1 neutralizing antibodies

David J. Evans
Jane McKeating
Jeffrey W. Almond
Research01 Jun 1989
Nature

Volume: 339, P: 385-388
Evaluation of a radioimminoassay for neuron specific enolase in small cell lung cancer

E H Cooper
T A Splinter
S L Pearson
Research01 Sept 1985
British Journal of Cancer

Volume: 52, P: 333-338
Megatherapy in children with high-risk Ewing’s sarcoma in first complete remission

L Madero
A Muñoz
S Salas
Research21 Apr 1998
Bone Marrow Transplantation

Volume: 21, P: 795-799
Functionally impaired plasmacytoid dendritic cells and non-haematopoietic sources of type I interferon characterize human autoimmunity

Type I interferon drives autoimmune pathology in SLE and has been assumed to come predominantly from plasmacytoid dendritic cells (pDCs). Here, the authors show that prior to the onset of SLE, pDCs lose multiple immunogenic functions and, instead, non-hematopoietic cells such as keratinocytes are a major source of type I interferons.

Antonios Psarras
Adewonuola Alase
Edward M. Vital
ResearchOpen Access01 Dec 2020
Nature Communications

Volume: 11, P: 1-18
Smith-specific regulatory T cells halt the progression of lupus nephritis

Antigen specific regulatory T cells (Treg) play key roles in the peripheral tolerance to suppress autoreactive immune cells and represent potential avenue for therapeutic intervention. Here the authors identify Smith specific Treg and engineer Treg based cell therapy showing suppression of inflammation in a murine model of lupus nephritis.

Peter J. Eggenhuizen
Rachel M. Y. Cheong
Joshua D. Ooi
ResearchOpen Access06 Feb 2024
Nature Communications

Volume: 15, P: 1-14
Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice

Autoimmunity mediated by age-associated B cells (ABC) can affect males and females differently. Here, using a lupus-like mouse model that affects females more severely, the authors observe an ABC mediated and guanine nucleotide exchange factor (GEF) restrained pathogenic process involving TLR7.

Edd Ricker
Michela Manni
Alessandra B. Pernis
ResearchOpen Access10 Aug 2021
Nature Communications

Volume: 12, P: 1-21
Gene-function studies in systemic lupus erythematosus

Multiple genes have been associated with susceptibility to systemic lupus erythematosus (SLE), but how do they promote disease development? In this Review, the authors examine the roles of a selected set of genes in the pathogenesis of SLE, and discuss how epigenetic modifications and microRNAs can mediate pathogenic changes in gene expression.

José C. Crispín
Christian M. Hedrich
George C. Tsokos
Reviews04 Jun 2013
Nature Reviews Rheumatology

Volume: 9, P: 476-484
Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation

Mitochondrial aspartate regulates ER morphology and co-translational translocation via BiP ADP ribosylation. In T cells from patients with rheumatoid arthritis, mitochondrial aspartate is deficient, resulting in ER expansion and excessive production of the pro-inflammatory cytokine TNF.

Bowen Wu
Tuantuan V. Zhao
Cornelia M. Weyand
Research22 Nov 2021
Nature Immunology

Volume: 22, P: 1551-1562
Arachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammation

ORAI3 is part of pore forming calcium channels involved in T cell activation. Here the authors show that there is increased expression of ORAI3 in T cells from patients with rheumatoid arthritis and that the transcription factor IKAROS negatively regulates the ORAI3 promoter, indicating a regulatory loop that can control auto-reactivity of T cells in these patients.

Zhongde Ye
Yi Shen
Jörg J. Goronzy
ResearchOpen Access10 Feb 2021
Nature Communications

Volume: 12, P: 1-17
Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon–mediated immunity

The protein isomerase Pin1 regulates the conformational state of signaling proteins. Lu and colleagues show that Pin1 has an essential role in Toll-like receptor signaling by regulating the adapter IRAK1.

Adrian Tun-Kyi
Greg Finn
Kun Ping Lu
Research10 Jul 2011
Nature Immunology

Volume: 12, P: 733-741
Mechanisms Controlling the Human Immunoglobulin E Response: New Directions in the Therapy of Allergic Diseases

Donald Y M Leung
Research01 Jan 1993
Pediatric Research

Volume: 33, P: S56-S62
Mechanisms Controlling the Human Immunoglobulin E Response: New Directions in the Therapy of Allergic Diseases

Donald Y M Leung
Research01 Apr 1993
Pediatric Research

Volume: 33, P: S56-S62
Abnormalities of Immune Regulation in Human Immunodeficiency Virus Infection

Gene M Shearer
Mario Clerici
Research01 Apr 1993
Pediatric Research

Volume: 33, P: S71-S75
Use of horseradish peroxidase for gene-directed enzyme prodrug therapy with paracetamol

J Tupper
G M Tozer
G U Dachs
ResearchOpen Access06 Apr 2004
British Journal of Cancer

Volume: 90, P: 1858-1862
A detailed study of loss of heterozygosity on chromosome 17 in tumours from Li – Fraumeni patients carrying a mutation to the TP53 gene

J M Varley
M Thorncroft
J M Birch
Research20 Feb 1997
Oncogene

Volume: 14, P: 865-871
Suppression of telomerase reverse transcriptase (hTERT) expression in differentiated HL-60 cells: regulatory mechanisms

D Xu
A Gruber
P Pisa
ResearchOpen Access28 May 1999
British Journal of Cancer

Volume: 80, P: 1156-1161
Interleukin 1 β synergises with interleukin 2 in the outgrowth of autologous tumour-reactive CD8⁺ effectors

CN Baxevanis
GVZ Dedoussis
M Papamichail
Research01 Oct 1994
British Journal of Cancer

Volume: 70, P: 625-630
MDM2 gene amplification and expression in non-small-cell lung cancer: immunohistochemical expression of its protein is a favourable prognostic marker in patients without p53 protein accumulation

M Higashiyama
O Doi
I Nishisho
Research01 May 1997
British Journal of Cancer

Volume: 75, P: 1302-1308
Sensitive detection of occult Ewing's cells by the reverse transcriptase-polymerase chain reaction

M Peter
H Magdelenat
O Delattre
Research01 Jul 1995
British Journal of Cancer

Volume: 72, P: 96-100
Mutational status of K- ras and TP53 genes in primary sarcomas of the heart

J M Garcia
R Gonzalez
F Bonilla
ResearchOpen Access22 Feb 2000
British Journal of Cancer

Volume: 82, P: 1183-1185
Urate oxidase in prevention and treatment of hyperuricemia associated with lymphoid malignancies

C-H Pui
MV Relling
HH Mahmoud
Research01 Nov 1997
Leukemia

Volume: 11, P: 1813-1816
Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas

Monica Fedele
Sabrina Battista
Alfredo Fusco
Research07 May 2002
Oncogene

Volume: 21, P: 3190-3198
Long-term suprapubic catheterisation: clinical outcome and satisfaction survey

M K M Sheriff
S Foley
P J R Shah
Research13 Mar 1998
Spinal Cord

Volume: 36, P: 171-176
A systemic review of Toxic Death in clinical oncology trials: an Achilles’ heel in safety reporting revisited

B Penninckx
W M Van de Voorde
M Karrasch
ResearchOpen Access07 Jun 2012
British Journal of Cancer

Volume: 107, P: 1-6
High levels of the MDM2 oncogene in paediatric rhabdomyosarcoma cell lines may confer multidrug resistance

H A Cocker
S M Hobbs
L R Kelland
ResearchOpen Access27 Nov 2001
British Journal of Cancer

Volume: 85, P: 1746-1752
P53 germline mutations in childhood cancers and cancer risk for carrier individuals

A Chompret
L Brugières
J Feunteun
ResearchOpen Access23 May 2000
British Journal of Cancer

Volume: 82, P: 1932-1937
Telomerase activity of the Lugol-stained and -unstained squamous epithelia in the process of oesophageal carcinogenesis

M Inai
M Kano
M Imamura
ResearchOpen Access02 Oct 2001
British Journal of Cancer

Volume: 85, P: 1006-1013
The latency pattern of Epstein–Barr virus infection and viral IL-10 expression in cutaneous natural killer/T-cell lymphomas

Z-G Xu
K Iwatsuki
F Kaneko
ResearchOpen Access03 Apr 2001
British Journal of Cancer

Volume: 84, P: 920-925
Identification of angiogenic properties of insulin-like growth factor II in in vitro angiogenesis models

O H Lee
S K Bae
K W Kim
ResearchOpen Access17 Dec 1999
British Journal of Cancer

Volume: 82, P: 385-391
Interleukin 1β mediates the modulatory effects of monocytes on LNCaP human prostate cancer cells

Z Culig
A Hobisch
G Konwalinka
Research01 Oct 1998
British Journal of Cancer

Volume: 78, P: 1004-1011
8-Cl-cAMP antagonizes mitogen-activated protein kinase activation and cell growth stimulation induced by epidermal growth factor

A Budillon
E Di Gennaro
P Tagliaferri
ResearchOpen Access12 Nov 1999
British Journal of Cancer

Volume: 81, P: 1134-1141
GR-891: a novel 5-fluorouracil acyclonucleoside prodrug for differentiation therapy in rhabdomyosarcoma cells

J A Marchal
J Prados
A Aránega
ResearchOpen Access29 Jan 1999
British Journal of Cancer

Volume: 79, P: 807-813
Beta-platelet-derived growth factor receptor mediates motility and growth of Ewing's sarcoma cells

A Üren
M S Merchant
J A Toretsky
Research17 Apr 2003
Oncogene

Volume: 22, P: 2334-2342
Forty years of retinoblastoma; into the fifth age

A C E McCartney
J M Olver
J L Hungerford
Reviews01 Jan 1988
Eye

Volume: 2, P: S13-S18
Redirecting mouse T hybridoma against human breast and ovarian carcinomas: in vivo activity against HER-2/neu expressing cancer cells

A D Gritzapis
A Mamalaki
M Papamichail
ResearchOpen Access15 Apr 2003
British Journal of Cancer

Volume: 88, P: 1292-1300
Myogenin is a Specific Marker for Rhabdomyosarcoma: An Immunohistochemical Study in Paraffin-Embedded Tissues

S Kumar
E Perlman
M Tsokos
Research01 Sept 2000
Modern Pathology

Volume: 13, P: 988-993
Human herpesvirus-6-associated acute lymphadenitis in immunocompetent adults

Irina Maric
Ron Bryant
Stefania Pittaluga
Research19 Oct 2004
Modern Pathology

Volume: 17, P: 1427-1433
NY-ESO-1 expression in synovial sarcoma and other mesenchymal tumors: significance for NY-ESO-1-based targeted therapy and differential diagnosis

Jin-Ping Lai
Paul F Robbins
Chyi-Chia Richard Lee
Research02 Mar 2012
Modern Pathology

Volume: 25, P: 854-858
Apoptotic cell death and cytokine dysregulation in human immunodeficiency virus infection: pivotal factors in disease progression

Mario Clerici
Apurva Sarin
Gene M Shearer
Reviews01 Dec 1997
Cell Death & Differentiation

Volume: 4, P: 699-706
A novel isoform of the orphan receptor RORγt suppresses IL-17 production in human T cells

T Rauen
Y-T Juang
G C Tsokos
Research12 Jan 2012
Genes & Immunity

Volume: 13, P: 346-350
The applied basic research of systemic lupus erythematosus based on the biological omics

W Sui
X Hou
Y Dai
Reviews28 Feb 2013
Genes & Immunity

Volume: 14, P: 133-146
Pathologic Classification of Rhabdomyosarcomas and Correlations with Molecular Studies

David M Parham
Reviews01 May 2001
Modern Pathology

Volume: 14, P: 506-514

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