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A combinatorial strategy for treating KRAS-mutant lung cancer

A systematic screen identifies FGFR1 signalling reactivation as an adaptive resistance mechanism after MEK inhibition specific for KRAS tumours, which can be targeted by combined inhibition with the clinically approved drugs trametinib and ponatinib.

Eusebio Manchado
Susann Weissmueller
Scott W. Lowe
Research22 Jun 2016
Nature

Volume: 534, P: 647-651
A derived neutrophil to lymphocyte ratio predicts clinical outcome in stage II and III colon cancer patients

G Absenger
J Szkandera
A Gerger
ResearchOpen Access02 Jul 2013
British Journal of Cancer

Volume: 109, P: 395-400

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A combinatorial strategy for treating KRAS-mutant lung cancer

A derived neutrophil to lymphocyte ratio predicts clinical outcome in stage II and III colon cancer patients

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