Nature Search

Single versus combination treatment in tinnitus: an international, multicentre, parallel-arm, superiority, randomised controlled trial

Chronic tinnitus is often treated with cognitive-behavioural therapy, hearing aids, counselling, or sound therapy, but their combined benefit is unclear. Here, the authors show, in a multicentre randomised trial, that combination treatments improve tinnitus scores more than single therapies, though benefits appear compensatory rather than synergistic.

Stefan Schoisswohl
Laura Basso
Winfried Schlee
ResearchOpen Access21 Nov 2025
Nature Communications

Volume: 16, P: 1-12
Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder

Genome-wide analyses identify 30 independent loci associated with obsessive–compulsive disorder, highlighting genetic overlap with other psychiatric disorders and implicating putative effector genes and cell types contributing to its etiology.

Nora I. Strom
Zachary F. Gerring
Manuel Mattheisen
ResearchOpen Access13 May 2025
Nature Genetics

Volume: 57, P: 1389-1401
Acute stress induces changes in epigenome-wide DNA methylation

Lea Zillich
Nathaly S. Czernin
Miriam A. Schiele
ResearchOpen Access12 Dec 2025
Neuropsychopharmacology

P: 1-9
Enantiospecific cross-coupling of cyclic alkyl sulfones

Cross-coupling reactions are among the most important carbon–carbon bond-forming reactions. Now the nickel-catalysed cross-coupling of chiral sulfones with Grignard reagents has been achieved with up to 99% retention of chirality. The speed of the cross-coupling relative to sulfone deprotonation and racemization is critical to enabling this enantiospecific process.

Roberto Nolla-Saltiel
Zachary T. Ariki
Cathleen M. Crudden
Research05 Aug 2024
Nature Chemistry

Volume: 16, P: 1445-1452
Seasonal and pandemic influenza: 100 years of progress, still much to learn

Jake Dunning
Ryan S. Thwaites
Peter J. M. Openshaw
Reviews21 Apr 2020
Mucosal Immunology

Volume: 13, P: 566-573
Methylome-wide association study of anxiety disorders

John M. Hettema
Edwin J. C. G. van den Oord
Shaunna L. Clark
Research04 Aug 2023
Molecular Psychiatry

Volume: 28, P: 3484-3492
Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils

An orcein-related small molecule can drive polymerization of amyloid-β, implicated in Alzheimer's disease, without remodeling oligomeric or fibril forms but by stabilizing a seeding-competent protofilament state and shortening the lag phase of spontaneous polymerization.

Jan Bieschke
Martin Herbst
Erich E Wanker
Research20 Nov 2011
Nature Chemical Biology

Volume: 8, P: 93-101
Connectomic reconstruction of the inner plexiform layer in the mouse retina

Improved electron microscopy methods are used to map a mammalian retinal circuit of close to 1,000 neurons; the work reveals a new type of retinal bipolar neuron and suggests functional mechanisms for known visual computations.

Moritz Helmstaedter
Kevin L. Briggman
Winfried Denk
Research07 Aug 2013
Nature

Volume: 500, P: 168-174
Can oral sirolimus therapy prevent in-stent restenosis?

Thomas M Schiele
Comments & Opinion01 Feb 2005
Nature Clinical Practice Cardiovascular Medicine

Volume: 2, P: 76-77
Exploring the association between serotonin transporter promoter region methylation levels and depressive symptoms: a systematic review and multi-level meta-analysis

F. Javelle
G. Dao
W. Bloch
ReviewsOpen Access03 May 2025
Translational Psychiatry

Volume: 15, P: 1-14
Individual differences in human fear generalization—pattern identification and implications for anxiety disorders

Y. Stegmann
M. A. Schiele
P. Pauli
ResearchOpen Access18 Nov 2019
Translational Psychiatry

Volume: 9, P: 1-11
Folate intake in Europe: recommended, actual and desired intake

A de Bree
M van Dusseldorp
RPM Steegers-Theunissen
Reviews01 Oct 1997
European Journal of Clinical Nutrition

Volume: 51, P: 643-660
A functional genetic variation of SLC6A2 repressor hsa-miR-579-3p upregulates sympathetic noradrenergic processes of fear and anxiety

L. G. Hommers
J. Richter
J. Deckert
ResearchOpen Access19 Oct 2018
Translational Psychiatry

Volume: 8, P: 1-12
Pretherapeutic gamma-glutamyltransferase is an independent prognostic factor for patients with renal cell carcinoma

S L Hofbauer
K I Stangl
T Klatte
ResearchOpen Access12 Aug 2014
British Journal of Cancer

Volume: 111, P: 1526-1531
The DNA methylome in panic disorder: a case-control and longitudinal psychotherapy-epigenetic study

Christiane Ziegler
Franziska Grundner-Culemann
Katharina Domschke
ResearchOpen Access21 Nov 2019
Translational Psychiatry

Volume: 9, P: 1-11
Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Maren Doenhardt
Markus Hufnagel
Ulrich Zügge
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-15
Flying under the radar: the new wave of BCR–ABL inhibitors

Chronic myeloid leukaemia caused by the mutant BCR–ABL kinase has been successfully treated with inhibitors of this kinase, such as imatinib, but mutations within the kinase can result in resistance to these drugs. Quintás-Cardama and colleagues discuss novel BCR–ABL inhibitors that have the potential to overcome such resistance.

Alfonso Quintás-Cardama
Hagop Kantarjian
Jorge Cortes
Reviews01 Oct 2007
Nature Reviews Drug Discovery

Volume: 6, P: 834-848
Janus kinase inhibitors for the treatment of myeloproliferative neoplasias and beyond

Activating mutations in Janus kinase 2 (JAK2) are a common feature of a number of myeloproliferative neoplasms. JAKs are also involved in the pathogenesis of inflammatory and immune-mediated disorders, and several JAK inhibitors are now in clinical development. In this Review, Quintás-Cardama and colleagues discuss the current progress in this field.

Alfonso Quintás-Cardama
Hagop Kantarjian
Srdan Verstovsek
Reviews01 Feb 2011
Nature Reviews Drug Discovery

Volume: 10, P: 127-140
GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder

J Deckert
H Weber
A Reif
Research07 Feb 2017
Molecular Psychiatry

Volume: 22, P: 1431-1439
MAOA gene hypomethylation in panic disorder—reversibility of an epigenetic risk pattern by psychotherapy

C Ziegler
J Richter
K Domschke
ResearchOpen Access05 Apr 2016
Translational Psychiatry

Volume: 6, P: e773

Search

Single versus combination treatment in tinnitus: an international, multicentre, parallel-arm, superiority, randomised controlled trial

Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder

Acute stress induces changes in epigenome-wide DNA methylation

Enantiospecific cross-coupling of cyclic alkyl sulfones

Seasonal and pandemic influenza: 100 years of progress, still much to learn

Methylome-wide association study of anxiety disorders

Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils

Connectomic reconstruction of the inner plexiform layer in the mouse retina

Can oral sirolimus therapy prevent in-stent restenosis?

Exploring the association between serotonin transporter promoter region methylation levels and depressive symptoms: a systematic review and multi-level meta-analysis

Individual differences in human fear generalization—pattern identification and implications for anxiety disorders

Folate intake in Europe: recommended, actual and desired intake

A functional genetic variation of SLC6A2 repressor hsa-miR-579-3p upregulates sympathetic noradrenergic processes of fear and anxiety

Pretherapeutic gamma-glutamyltransferase is an independent prognostic factor for patients with renal cell carcinoma

The DNA methylome in panic disorder: a case-control and longitudinal psychotherapy-epigenetic study

Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Flying under the radar: the new wave of BCR–ABL inhibitors

Janus kinase inhibitors for the treatment of myeloproliferative neoplasias and beyond

GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder

MAOA gene hypomethylation in panic disorder—reversibility of an epigenetic risk pattern by psychotherapy

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