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Showing 1–5 of 5 results
Advanced filters: Author: M. A. Voronkov Clear advanced filters

  • The authors developed a small molecule targeting the circadian regulator BMAL1, enabling dose-dependent modulation of gene expression for circadian-controlled genes and downregulation of inflammatory pathways in macrophages.

    • Hua Pu
    • Laura C. Bailey
    • Fraydoon Rastinejad
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 21, P: 736-745

  • Using commissioning data from the Australian Square Kilometre Array Pathfinder (ASKAP), parts of the Small Magellanic Cloud (SMC) have been mapped with ten times the resolution of before. Cold H i outflows are found to extend some 2 kpc from the SMC bar, containing up to 3% of the galaxy’s atomic mass. These will probably be stripped by interactions with neighbouring galaxies.

    • N. M. McClure-Griffiths
    • H. Dénes
    • M. Whiting
    Research
    Nature Astronomy
    Volume: 2, P: 901-906

  • Resistance to first line treatment is a major hurdle in cancer treatment, that can be overcome with drug combinations. Here, the authors provide a large drug combination screen across cancer cell lines to benchmark crowdsourced methods and to computationally predict drug synergies.

    • Michael P. Menden
    • Dennis Wang
    • Julio Saez-Rodriguez
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17