Nature Search

The FitzGerald-Lorentz Effect

W. M. HICKS
Research13 Feb 1902
Nature

Volume: 65, P: 343
Integrated epidemiological and molecular data inform the relationship between precancer and cancer states of esophageal adenocarcinoma

Analyses of epidemiological, clinical and molecular data from a prospective cohort of 3,100 patients with esophageal carcinoma suggest intestinal metaplasia as a single precancer pathway preceding the disease.

Shahriar A. Zamani
Lianlian Wu
Rebecca C. Fitzgerald
ResearchOpen Access16 Apr 2026
Nature Medicine

P: 1-12
Pancreatic Acinar Cell Regeneration

PATRICK J. FITZGERALD
BERNARD M. CAROL
LAWRENCE ROSENSTOCK
Research01 Nov 1966
Nature

Volume: 212, P: 594-596
Evolutionary characterization of lung cancer metastasis

DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-small cell lung cancer and the seeding patterns that underpin it.

Sonya Hessey
Abigail Bunkum
Mariam Jamal-Hanjani
ResearchOpen Access29 Apr 2026
Nature

P: 1-14
A spatially coordinated keratinocyte–fibroblast circuit recruits MMP9⁺ myeloid cells to drive type I interferon-driven inflammation in photosensitive autoimmunity

Wang, Afshari, Haddadi and colleagues compare UVB-sensitive and insensitive human skin diseases and show that photosensitive conditions, including cutaneous lupus erythematosus and dermatomyositis, have increased type I interferon activity and an expanded MMP9⁺CD14⁺ myeloid population that drives inflammation.

Yuqing Wang
Khashayar Afshari
Manuel Garber
ResearchOpen Access24 Apr 2026
Nature Immunology

P: 1-13
Resolution of R-loops and transcription–replication conflicts by SETX–BRCA1–BARD1 complex

Dutta et al. demonstrate that the tumor suppressor complex BRCA1–BARD1 physically interacts with the RNA–DNA helicase Senataxin (SETX) and upregulates the activity of SETX to resolve harmful R-loops crucial for the avoidance of transcription–replication conflicts.

Arijit Dutta
Jae-Hoon Ji
Patrick Sung
Research31 Mar 2026
Nature Structural & Molecular Biology

Volume: 33, P: 615-630
A New Experimental Test of Special Relativity

J. P. CEDARHOLM
C. H. TOWNES
Research31 Oct 1959
Nature

Volume: 184, P: 1350-1351
Mechanism of Lymphocyte Transformation induced by Phytohaemagglutinin

M. J. SIMONS
R. FOWLER
M. G. FITZGERALD
Research07 Sept 1968
Nature

Volume: 219, P: 1021-1025
A ligand-gated, hinged loop rearrangement opens a channel to a buried artificial protein cavity

Melissa M. Fitzgerald
Rabi A. Musah
David B. Goodin
Research01 Jul 1996
Nature Structural Biology

Volume: 3, P: 626-631
Variations in mercury deposition to Antarctica over the past 34,000 years

Grace M. Vandal
William F. Fitzgerald
Jean-Pierre Candelone
Research15 Apr 1993
Nature

Volume: 362, P: 621-623
Lyman-Alpha Photographs of the Sun

J. D. PURCELL
D. M. PACKER
R. TOUSEY
Research04 Jul 1959
Nature

Volume: 184, P: 8-10
Induction of Dental Caries in Gnotobiotic Rats by Streptococci of Human Origin

DORAN D. ZINNER
ANA P. ARAN
ROBERT J. FITZGERALD
Research14 Jan 1967
Nature

Volume: 213, P: 200-201
An outer membrane vesicle vaccine prevents lung pathology in a macaque model of pneumonic melioidosis

Currently, there is no licensed vaccine for Burkholderia pseudomallei, the causative agent of melioidosis. Here, the authors evaluate the efficacy and safety of an outer-membrane vesicle vaccine in macaques and demonstrate that it prevents lung pathology.

Sarah M. Baker
Erik W. Settles
Lisa A. Morici
ResearchOpen Access09 Dec 2025
Nature Communications

Volume: 17, P: 1-12
Flightless bird from the Cretaceous of Mongolia

Perle Altangerel
Mark A. Norell
James M. Clark
Research15 Apr 1993
Nature

Volume: 362, P: 623-626
Sulfur-containing class of broad-spectrum antivirals improves influenza virus vaccine development

Improved vaccines and antivirals are needed for many enveloped viruses. Here, the authors identify sulfur-based small molecules that disrupt viral membrane properties, inhibiting fusion and entry, and safely inactivate influenza virus. The resulting inactivated influenza vaccine is protective in mice.

David W. Buchholz
Armando Pacheco
Hector C. Aguilar
ResearchOpen Access06 Jan 2026
Nature Communications

Volume: 17, P: 1-14
Quantifying sleep wake rhythms in the hospital environment with digital technologies

Carsten Skarke
Nadim El Jamal
Garret A. FitzGerald
ResearchOpen Access21 Apr 2026
npj Digital Medicine

P: 1-10
Small molecule BLVRB redox inhibitor promotes megakaryocytopoiesis and stress thrombopoiesis in vivo

The heme degradation enzyme biliverdin IXβ reductase (BLVRB) is implicated in a redox-regulated thrombopoietic pathway. Here, the authors validate BLVRB as a cellular target by generating an orally-available small molecule inhibitor that retains platelet-enhancing functions that are mechanistically distinct from thrombopoietin receptor-targeted mimetics.

Natasha M. Nesbitt
Gian Luca Araldi
Wadie F. Bahou
ResearchOpen Access11 Apr 2025
Nature Communications

Volume: 16, P: 1-18
Vesicular transport between the endoplasmic reticulum and the Golgi stack requires the NEM-sensitive fusion protein

Con J. M. Beckers
Marc R. Block
William E. Balch
Research01 Jun 1989
Nature

Volume: 339, P: 397-398
Vibriostatic Activity in Certain Series of Pteridines

H. O. J. COLLIER
N. R. CAMPBELL
M. E. H. FITZGERALD
Research24 Jun 1950
Nature

Volume: 165, P: 1004-1005
ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1

Yersiania YopJ protein has been shown to drive caspase-8-mediated pyroptosis. Here the authors show a precise mechanism of this non-canonical cell death pathway that is controlled by a TRIF-dependent complex of FADD, RIPK1, caspase-8 and ZBP1.

Hayley I. Muendlein
Wilson M. Connolly
Alexander Poltorak
ResearchOpen Access04 Jan 2021
Nature Communications

Volume: 12, P: 1-13
15-Lipoxygenase promotes resolution of inflammation in lymphedema by controlling T_reg cell function through IFN-β

Specialised pro-resolving lipid mediators can reduce inflammatory responses and may be active in lymphedema. Here the authors show that in a mouse model 15-LO derived lipid mediators are reduced during inflammation and that a lack of the 15-LO producing enzyme aggravated disease and addition of 15-LO enzyme or Treg cells reduced disease.

A. Zamora
M. Nougué
B. Garmy-Susini
ResearchOpen Access04 Jan 2024
Nature Communications

Volume: 15, P: 1-14
A chaperone-proteasome-based fragmentation machinery is essential for aggrephagy

Mauthe et al. find that protein aggregate clearance requires fragmentation of the aggregate by a chaperone module and a proteasomal regulatory particle for recruitment and clustering of selective autophagy receptors to initiate phagophore formation.

Mario Mauthe
Nicole van de Beek
Fulvio Reggiori
ResearchOpen Access27 Aug 2025
Nature Cell Biology

Volume: 27, P: 1448-1464
IgG-cleaving endopeptidase enables in vivo gene therapy in the presence of anti-AAV neutralizing antibodies

An IgG-cleaving endopeptidase can degrade circulating anti-adeno-associated virus antibodies in mice and nonhuman primates in vivo, as well as in human plasma in vitro, offering a potential solution for a major hurdle in gene therapy.

Christian Leborgne
Elena Barbon
Federico Mingozzi
Research01 Jun 2020
Nature Medicine

Volume: 26, P: 1096-1101
Pulmonary function testing in the Emergency Department and medications prescribed at discharge: results of the Multinational Acute asthma Management, Burden, and Outcomes (MAMBO) study

J Mark Fitzgerald
Paul M O'Byrne
Felicia C Allen-Ramey
Research26 Jan 2010
Primary Care Respiratory Journal

Volume: 19, P: 155-162
Removal of sulphur from the marine boundary layer by ozone oxidation in sea-salt aerosols

H. Sievering
J. Boatman
S. Pandis
Research10 Dec 1992
Nature

Volume: 360, P: 571-573
Caenorhabditis elegans expressed sequence tags identify gene families and potential disease gene homologues

W. Richard McCombie
Mark D. Adams
Chris Fields
Research01 May 1992
Nature Genetics

Volume: 1, P: 124-131
Bifidobacterium longum and prebiotic interventions restore early-life high-fat/high-sugar diet-induced alterations in feeding behavior in adult mice

Here, the authors show that early-life high-fat/high-sugar diet induces sex-specific alterations in adult feeding behavior, hypothalamic transcriptome and blood metabolome, with Bifidobacterium longum and prebiotic FOS + GOS administration restoring these effects via distinct mechanisms, highlighting their therapeutic potential.

Cristina Cuesta-Marti
Eduardo Ponce-España
Harriët Schellekens
ResearchOpen Access24 Feb 2026
Nature Communications

Volume: 17, P: 1-27
Radiocarbon dating of the Shroud of Turin

P. E. Damon
D. J. Donahue
M. S. Tite
Research16 Feb 1989
Nature

Volume: 337, P: 611-615
Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants

A modularized open-source pipeline for invasive brain signal decoding bridges the gap between closed-loop neuromodulation and clinical brain–computer interface approaches in a large patient cohort.

Timon Merk
Richard M. Köhler
Wolf-Julian Neumann
ResearchOpen Access24 Sept 2025
Nature Biomedical Engineering

P: 1-18
Mercury in the Kuroshio and Oyashio regions and the Japan Sea

K. MATSUNAGA
M. NISHIMURA
S. KONISHI
Research20 Nov 1975
Nature

Volume: 258, P: 224-225
Detection of Radiophosphorus in Cells and Spores of Fungi by Radioautography

A. M. ADAMS
J. J. MILLER
Research09 Aug 1952
Nature

Volume: 170, P: 239
Microglia promote inflammatory cell death upon neuronal mitochondrial impairment during neurodegeneration

Miao et al. show that loss of neuronal Vps13d in mice leads to mitochondrial dysfunction, GSDME-mediated mitochondrial DNA release, cGAS–STING inflammatory signaling and activation of microglia, culminating in neuronal loss.

Guangyan Miao
Tina M. Fortier
Eric H. Baehrecke
Research25 Jun 2025
Nature Structural & Molecular Biology

Volume: 32, P: 2046-2059
Stimulation of Biosynthesis of Glyceride

G. HÜBSCHER
D. N. BRINDLEY
B. SEDGWICK
Research01 Nov 1967
Nature

Volume: 216, P: 449-453
Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice

The circadian clock protein REV-ERBα has been implicated in neuroinflammation but mechanisms are poorly understood. Here, the authors show that microglial REV-ERBα regulates inflammatory signaling and lipid droplet formation to exert sex-specific effects on tau pathology in mice.

Jiyeon Lee
Julie M. Dimitry
Erik S. Musiek
ResearchOpen Access25 Aug 2023
Nature Communications

Volume: 14, P: 1-17
Somatotopic maps are disorganized in adult rodents treated neonatally with capsaicin

P. D. Wall
M. Fitzgerald
M. Devor
Research25 Feb 1982
Nature

Volume: 295, P: 691-693
Aflatoxin: Effect on Cultured Heteroploid Human Embryonic Lung Cells

MARVIN S. LEGATOR
SAVERIO M. ZUFFANTE
ANTHONY R. HARP
Research23 Oct 1965
Nature

Volume: 208, P: 345-347
Functional phenotyping of genomic variants using joint multiomic single-cell DNA–RNA sequencing

This study introduces SDR-seq, a droplet-based single-cell DNA–RNA sequencing platform, enabling the study of gene expression profiles linked to both noncoding and coding variants.

Dominik Lindenhofer
Julia R. Bauman
Lars M. Steinmetz
ResearchOpen Access01 Sept 2025
Nature Methods

Volume: 22, P: 2032-2041
Familial hyperinsulinism maps to chromosome 11p14–15.1, 30 cM centromeric to the insulin gene

B. Glaser
K.C. Chiu
M.A. Permutt
Research01 Jun 1994
Nature Genetics

Volume: 7, P: 185-188
Ionization states of the catalytic residues in HIV-1 protease

Ross Smith
Ian M. Brereton
Stephen B.H. Kent
Research01 Nov 1996
Nature Structural Biology

Volume: 3, P: 946-950
Structure of human neutrophil collagenase reveals large S1′ specificity pocket

Travis Stams
John C. Spurlino
Byron Rubin
Research01 Feb 1994
Nature Structural Biology

Volume: 1, P: 119-123
LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes

LONP1, whose expression is downregulated in islets from donors with type 2 diabetes, is vital to mediate efficient mitochondrial protein folding, thus preventing proteotoxicity and promoting islet β cell survival and function.

Jin Li
Yamei Deng
Scott A. Soleimanpour
ResearchOpen Access21 Jul 2025
Nature Metabolism

Volume: 7, P: 1570-1592
Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression

It is now shown that tumour-associated macrophages recruited early during tumour evolution stimulate stromal fibroblasts to express collagen crosslinking enzymes and that the stromal expression, particularly of lysyl hydroxylase 2, can predict survival in a patient cohort.

Ori Maller
Allison P. Drain
Valerie M. Weaver
Research30 Nov 2020
Nature Materials

Volume: 20, P: 548-559
Protein microarrays with carbon nanotubes as multicolor Raman labels

The picomolar sensitivity of fluorescence-based protein detection limits the use of protein arrays in research and clinical diagnosis. Chen et al. use antibody-tagged single-walled carbon nanotubes as multicolor Raman labels to detect femtomolar levels of serum analytes over a wide dynamic range.

Zhuo Chen
Scott M Tabakman
Hongjie Dai
Research26 Oct 2008
Nature Biotechnology

Volume: 26, P: 1285-1292
Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

Bernardo Rodriguez-Martin
Eva G. Alvarez
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Genetics

Volume: 52, P: 306-319
Sequence from spectrometry: A realistic prospect?

Lloyd M. Smith
Research01 Sept 1996
Nature Biotechnology

Volume: 14, P: 1084-1087
Latent Viruses in Chimpanzees with Experimental Kuru

NANCY G. ROGERS
M. BASNIGHT
D. C. GAJDUSEK
Research01 Nov 1967
Nature

Volume: 216, P: 446-449
β-Chain contact sites in the haemoglobin S polymer

R. L. Nagel
J. Johnson
O. Castro
Research28 Feb 1980
Nature

Volume: 283, P: 832-834
Requirement for nerve growth factor in the development of myelinated nociceptors in vivo

Amy M. Ritter
Gary R. Lewin
Lorne M. Mendell
Research11 Apr 1991
Nature

Volume: 350, P: 500-502
Lower Tertiary Microfossils from McMurdo Sound, Antarctica

LUCY M. CRANWELL
H. J. HARRINGTON
I. G. SPEDEN
Research28 May 1960
Nature

Volume: 186, P: 700-702
A procedure for rule extraction from a Self-Organising plasma disruption predictor for JET

Samuele Setzu
Enrico Aymerich
I. Zychor
ResearchOpen Access10 Apr 2026
Scientific Reports

P: 1-21

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