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Showing 1–6 of 6 results
Advanced filters: Author: M. E. Mikucki Clear advanced filters

  • Tumours secrete many lymphocyte-attracting chemokines. Here the authors show that despite the abundance of their ligands, CCR2 and CCR5 do not mediate trafficking of effector CD8 T cells into the tumour, whereas CXCR3 is essential for this process and for T-cell-based elimination of melanoma in mice.

    • M. E. Mikucki
    • D. T. Fisher
    • S. S. Evans
    Research
    Nature Communications
    Volume: 6, P: 1-14

  • Antarctica has an essential role in regulating Earth's climate and ocean ecosystem function, and Antarctica's biosphere is dominated by microorganisms. In this Review, Cavicchioli discusses the factors that shape the biogeography of Antarctic microorganisms and explores how 'omic' studies have begun to elucidate the mechanisms determining the composition and function of microbial communities in Antarctic aquatic systems.

    • Ricardo Cavicchioli
    Reviews
    Nature Reviews Microbiology
    Volume: 13, P: 691-706

  • In this Review, Mempel et al. use our understanding of the physiological response programmes of the immune system to the more commonplace challenges it encounters as a framework to interpret observations of chemokine function in tumours. When viewed in this way, the design of more effective therapeutic interventions leveraging the chemokine system to recalibrate response patterns to cancer might be possible.

    • Thorsten R. Mempel
    • Julia K. Lill
    • Lukas M. Altenburger
    Reviews
    Nature Reviews Cancer
    Volume: 24, P: 28-50

  • In this Review, Boetiuset al. summarize our current knowledge of the microbial ecology of Earth's frozen realms, including sea ice and glacial habitats. They describe the diversity of niches, the composition of microbial communities at these sites and their biogeochemical activities.

    • Antje Boetius
    • Alexandre M. Anesio
    • Josephine Z. Rapp
    Reviews
    Nature Reviews Microbiology
    Volume: 13, P: 677-690

  • There has been active debate over microbial life in Antarctic subglacial lakes owing to a paucity of direct observations from beneath the ice sheet and concerns about contamination in the samples that do exist; here the authors present the first geomicrobiological description of pristine water and surficial sediments from Subglacial Lake Whillans, and show that the lake water contains a diverse microbial community, many members of which are closely related to chemolithoautotrophic bacteria and archaea.

    • Brent C. Christner
    • John C. Priscu
    • S. Tulaczyk
    Research
    Nature
    Volume: 512, P: 310-313