Loss of function of the kinase PINK1 is associated with familial early-onset Parkinson’s disease and impaired clearance of damaged mitochondria. Here the authors show that the resulting oxidative stress activates the hypoxia regulator HIF1α, resulting in increased glycolysis and cell proliferation.
- Raquel Requejo-Aguilar
- Irene Lopez-Fabuel
- Juan P. Bolaños
