Nature Search

Oncogene aberrations drive medulloblastoma progression, not initiation

A large-scale multi-omics analysis reports oncogenic alterations that drive medulloblastoma progression, rather than initiation, and the findings show how single-cell technologies can be used for early detection and diagnosis of medulloblastoma.

Konstantin Okonechnikov
Piyush Joshi
Stefan M. Pfister
ResearchOpen Access07 May 2025
Nature

Volume: 642, P: 1062-1072
Comparative analysis of dielectric, shear mechanical and light scattering response functions in polar supercooled liquids

K. L. Ngai
Z. Wojnarowska
M. Paluch
ResearchOpen Access12 Nov 2021
Scientific Reports

Volume: 11, P: 1-15
Multi-omic and single-cell profiling of chromothriptic medulloblastoma reveals genomic and transcriptomic consequences of genome instability

Chromothripsis (CT) is a type of genome instability which is prevalent in medulloblastoma with germline TP53 mutations (Li-Fraumeni syndrome, LFS). Here the authors combine single-cell genomic and transcriptomic analyses to reveal the clonal heterogeneity and functional consequences of CT in LFS medulloblastoma.

Petr Smirnov
Moritz J. Przybilla
Aurélie Ernst
ResearchOpen Access23 Nov 2024
Nature Communications

Volume: 15, P: 1-20
Clonal tracing with somatic epimutations reveals dynamics of blood ageing

The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing through cellular differentiation at scale.

Michael Scherer
Indranil Singh
Lars Velten
ResearchOpen Access21 May 2025
Nature

Volume: 643, P: 478-487
Emergent coherent modes in nonlinear magnonic waveguides detected at ultrahigh frequency resolution

The authors realize the generation and electrical detection of nonlinear magnons in a ferrimagnetic insulator, giving rise to secondary nonlinear magnons with fine frequency structures on the order of a few MHz and specific propagation characteristics.

K. An
M. Xu
D. Grundler
ResearchOpen Access24 Aug 2024
Nature Communications

Volume: 15, P: 1-9
Cell Painting PLUS: expanding the multiplexing capacity of Cell Painting-based phenotypic profiling using iterative staining-elution cycles

This study presents the Cell Painting PLUS assay, a customisable phenotypic screening assay for multiplexed, iterative staining of single cells with seven fluorescent dyes for detailed mode-of-action analyses in toxicology and biomedical research.

Elena von Coburg
Marlene Wedler
Shu Liu
ResearchOpen Access24 Apr 2025
Nature Communications

Volume: 16, P: 1-21
Spatio-temporal transcriptomics of chromothriptic SHH-medulloblastoma identifies multiple genetic clones that resist treatment and drive relapse

The molecular landscape of chromothriptic medulloblastoma remains to be characterised. Here, spatial transcriptomics analysis of 13 chromothriptic and non-chromothriptic medulloblastomas identifies distinct spatial composition patterns and cell communication networks in these tumours.

Ilia Kats
Milena Simovic-Lorenz
Aurélie Ernst
ResearchOpen Access29 Nov 2024
Nature Communications

Volume: 15, P: 1-19
Resonant tunnelling and negative differential conductance in graphene transistors

Multilayer stacks of graphene and related two-dimensional crystals can be tailored to create new classes of functional materials. Britnell et al. report resonant tunnelling of Dirac fermions and tunable negative differential conductance in a graphene-boron nitride-graphene transistor.

L. Britnell
R. V. Gorbachev
L. Eaves
ResearchOpen Access30 Apr 2013
Nature Communications

Volume: 4, P: 1-5
Strong Coulomb drag and broken symmetry in double-layer graphene

Two closely spaced two-dimensional systems can remain strongly coupled by electron–electron interactions even though they cannot physically exchange particles. Coulomb drag is a manifestation of this interaction—in which an electric current passed through one layer causes frictional charge flow in the other—now experimentally observed in bilayer graphene

R. V. Gorbachev
A. K. Geim
L. A. Ponomarenko
Research14 Oct 2012
Nature Physics

Volume: 8, P: 896-901
Commensurate–incommensurate transition in graphene on hexagonal boron nitride

A single layer of graphene on top of a hexagonal boron-nitride sheet can stretch to form a commensurate structure, or not — depending on the rotation angle between the two layers. In the case of commensurability, strain gets concentrated in domain walls, resulting in soliton-like structures.

C. R. Woods
L. Britnell
K. S. Novoselov
Research28 Apr 2014
Nature Physics

Volume: 10, P: 451-456
Decoherence-protected memory for a single-photon qubit

A quantum memory based on a rubidium atom shows a record-long storage time of 100 ms with a readout efficiency of 22%. The photonic qubit is transferred between a basis with strong light–matter coupling and a basis with low decoherence.

M. Körber
O. Morin
G. Rempe
Research11 Dec 2017
Nature Photonics

Volume: 12, P: 18-21
Scalable multiparticle entanglement of trapped ions

H. Häffner
W. Hänsel
R. Blatt
Research01 Dec 2005
Nature

Volume: 438, P: 643-646
Deterministic quantum teleportation with atoms

M. Riebe
H. Häffner
R. Blatt
Research17 Jun 2004
Nature

Volume: 429, P: 734-737
TRF1 is a stem cell marker and is essential for the generation of induced pluripotent stem cells

TRF-1 is a telomere-binding protein that protects chromosome ends from degradation. Schneider and colleagues show that TRF1 is a marker of adult stem cell compartments and of induced pluripotent stem cells, and that TRF1 is essential for the induction and maintenance of pluripotency.

Ralph P. Schneider
Ianire Garrobo
Maria A. Blasco
Research05 Jun 2013
Nature Communications

Volume: 4, P: 1-16
Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma

A single-cell transcriptomic analysis of neuroblastomas and healthy adrenal glands defines cell types and lineage trajectories during different developmental stages. Comparisons with the transcriptomes of neuroblastoma cells show that their transcriptomes most closely resemble those of developing neuroblasts of the adrenal gland.

Selina Jansky
Ashwini Kumar Sharma
Frank Westermann
Research25 Mar 2021
Nature Genetics

Volume: 53, P: 683-693
Interference and dynamics of light from a distance-controlled atom pair in an optical cavity

Unconventional interference and statistics of photon fields are studied using two-state ⁸⁷Rb atoms interacting with photons in an optical cavity. The observations are well described by the Tavis-Cummings model in the strong-coupling regime.

A. Neuzner
M. Körber
G. Rempe
Research29 Feb 2016
Nature Photonics

Volume: 10, P: 303-306
Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line

Complex traits associate with genetic variation and environment and their interaction. Here, the authors study the influence of different diets on trait variability in 1154 outbred mice from an advanced intercross line and find gene-diet interactions associated with spontaneous autoimmunity development in these animals.

Artem Vorobyev
Yask Gupta
Ralf J. Ludwig
ResearchOpen Access10 Sept 2019
Nature Communications

Volume: 10, P: 1-15
Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status

High-grade serous ovarian cancer is the most common and aggressive ovarian cancer, with uncertain cell of origin. Here, the authors undertake a mass spectrometric analysis of 26 cancer cell lines and identify a protein signature that classifies ovarian cancer tissues into epithelial and mesenchymal groups.

F. Coscia
K. M. Watters
M. Mann
ResearchOpen Access26 Aug 2016
Nature Communications

Volume: 7, P: 1-14
Emissions from conventional and electronic waterpipes relative to cigarettes and a heated tobacco product

Peter J. Wilkinson
Anna Clarke
Ronan Barry
ResearchOpen Access30 Apr 2025
Scientific Reports

Volume: 15, P: 1-10
Author Correction: Multi-omic and single-cell profiling of chromothriptic medulloblastoma reveals genomic and transcriptomic consequences of genome instability

Petr Smirnov
Moritz J. Przybilla
Aurélie Ernst
Amendments and CorrectionsOpen Access27 Jan 2025
Nature Communications

Volume: 16, P: 1
The dielectric response of phenothiazine-based glass-formers with different molecular complexity

M. Rams-Baron
A. Jędrzejowska
M. Paluch
ResearchOpen Access04 Aug 2021
Scientific Reports

Volume: 11, P: 1-14
Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts

The authors find that stromal methyltransferase nicotinamide N-methyltransferase (NNMT) regulates the transition of normal fibroblasts to cancer-associated fibroblasts through histone methylation and promotes ovarian cancer growth and metastasis.

Mark A. Eckert
Fabian Coscia
Ernst Lengyel
Research01 May 2019
Nature

Volume: 569, P: 723-728
‘Designer atoms’ for quantum metrology

In quantum metrology, entangled states can be used to improve the signal-to-noise ratio. The use of a specially designed, entangled state of two Ca⁺ ions achieves an ultra-precise spectroscopic measurement of the electric quadrupole moment.

C. F. Roos
M. Chwalla
R. Blatt
Research21 Sept 2006
Nature

Volume: 443, P: 316-319
Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites

The shelterin complex binds and protects mammalian telomeres. The shelterin component, Rap1, binds to non-telomeric regions and has extra-telomeric functions in transcriptional gene regulation.

Paula Martinez
Maria Thanasoula
Maria A. Blasco
Research11 Jul 2010
Nature Cell Biology

Volume: 12, P: 768-780
Environmentally mediated synergy between perception and behaviour in mobile robots

Paul F. M. J. Verschure
Thomas Voegtlin
Rodney J. Douglas
Research09 Oct 2003
Nature

Volume: 425, P: 620-624
Cloning of Dirac fermions in graphene superlattices

Placing graphene on a boron nitride substrate and accurately aligning their crystallographic axes, to form a moiré superlattice, leads to profound changes in the graphene’s electronic spectrum.

L. A. Ponomarenko
R. V. Gorbachev
A. K. Geim
Research15 May 2013
Nature

Volume: 497, P: 594-597
Successful cryopreservation of purified autologous CD34⁺ cells: influence of freezing parameters on cell recovery and engraftment

F Beaujean
J-H Bourhis
JL Pico
Research03 Dec 1998
Bone Marrow Transplantation

Volume: 22, P: 1091-1096
Early childhood height-adjusted total kidney volume as a risk marker of kidney survival in ARPKD

Kathrin Burgmaier
Samuel Kilian
Hulya Nalcacioglu
ResearchOpen Access04 Nov 2021
Scientific Reports

Volume: 11, P: 1-10
Increased lipid utilization in weight losing and weight stable cancer patients with normal body weight

J Körber
S Pricelius
MJ Müller
Research24 Sept 1999
European Journal of Clinical Nutrition

Volume: 53, P: 740-745
Cerebellar and hepatic alterations in ACBD5-deficient mice are associated with unexpected, distinct alterations in cellular lipid homeostasis

Darwisch, von Spangenberg et al. show that ACBD5‐deficient mice exhibit elevated levels of very long‐chain fatty acids and a progressive cerebellar pathology. A complex metabolic phenotype suggests that ACBD5 with its acyl‐CoA binding and peroxisome‐ER tethering functions might contribute to the regulation of anabolic and catabolic cellular lipid pathways.

Warda Darwisch
Marino von Spangenberg
Markus Islinger
ResearchOpen Access26 Nov 2020
Communications Biology

Volume: 3, P: 1-19
Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins

Telomeres protect chromosomes from degradation and are therefore essential for ensuring genomic stability. These heterochromatic structures are bound by the shelterin complex, which regulates the activity of telomerase at the ends of chromosomes. This Review analyses the role of these telomeric proteins in cancer and ageing through modulating telomere length and protection, as well as through their 'extracurriculum' activities as gene expression regulators by binding to non-telomeric sites.

Paula Martínez
María A. Blasco
Reviews24 Feb 2011
Nature Reviews Cancer

Volume: 11, P: 161-176
Neddylation regulates excitatory synaptic transmission and plasticity

Marisa M. Brockmann
Michael Döngi
Valentin Stein
ResearchOpen Access29 Nov 2019
Scientific Reports

Volume: 9, P: 1-10

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