Viral protein X from HIV-2/SIV targets the HUSH (TASOR, MPP8 and periphilin) complex for proteasomal degradation through recruitment of the DCAF1 ubiquitin ligase adaptor, enabling reactivation of latent proviruses.
- Ghina Chougui
- Soundasse Munir-Matloob
- Florence Margottin-Goguet