Nature Search

CDKN2A and CDK4 mutation analysis in Italian melanoma-prone families: functional characterization of a novel CDKN2A germ line mutation

G Della Torre
B Pasini
M A Pierotti
ResearchOpen Access11 Sept 2001
British Journal of Cancer

Volume: 85, P: 836-844
Detailed computational study of p53 and p16: using evolutionary sequence analysis and disease-associated mutations to predict the functional consequences of allelic variants

M S Greenblatt
J G Beaudet
J P Bond
Research27 Feb 2003
Oncogene

Volume: 22, P: 1150-1163
Enhancement of anaerobic glycolysis – a role of PGC-1α4 in resistance exercise

Resistance exercise training (RET) is an effective countermeasure to sarcopenia, related frailty and metabolic disorders. Here, the authors show that an RET-induced increase in PGC-1α4 expression not only promotes muscle hypertrophy but also enhances glycolysis, providing a rapid supply of ATP for muscle contractions.

Jin-Ho Koh
Mark W. Pataky
K. Sreekumaran Nair
ResearchOpen Access28 Apr 2022
Nature Communications

Volume: 13, P: 1-15
Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance

PGC-1α is activated by exercise and promotes resistance to fatigue in muscles. Here, the authors show that PGC-1α activates the malate-aspartate shuttle, and allows muscle to utilise kynurenine, leading to more efficient glucose oxidation and mitochondrial respiration.

Leandro Z. Agudelo
Duarte M. S. Ferreira
Jorge L. Ruas
ResearchOpen Access24 Jun 2019
Nature Communications

Volume: 10, P: 1-12
The mitochondrial mRNA-stabilizing protein SLIRP regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms

Muscle mass is lost in patients with diabetes, which is associated with mitochondrial disfunction. Here they show that SLIRP maintains muscle mitochondria and that exercise training can compensate for SLIRP loss, improving mitochondrial function and quality control in muscle.

Tang Cam Phung Pham
Steffen Henning Raun
Lykke Sylow
ResearchOpen Access13 Nov 2024
Nature Communications

Volume: 15, P: 1-21
Activation of protein kinase C promotes human cancer cell growth through downregulation of p18^INK4c

Youichirou Matsuzaki
Yuuki Takaoka
Toshiyuki Sakai
Research26 Apr 2004
Oncogene

Volume: 23, P: 5409-5414
Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism

Exercise induces structural and functional adaptations in skeletal muscle that involve transcriptomic remodeling, including of miRNA expression. Here the authors examine the expression of miRNAs in human muscle following exercise training and investigate the functions of miR-19b-3p on glucose metabolism in cells and mouse muscle.

Julie Massart
Rasmus J. O. Sjögren
Anna Krook
ResearchOpen Access12 Oct 2021
Nature Communications

Volume: 12, P: 1-13
Multivalent insulin receptor activation using insulin–DNA origami nanostructures

DNA-origami-based insulin assembly into well-defined nanoclusters reveals that insulin valency and spatial organization modulate insulin receptor activation and downstream responses independent of ligand concentration.

Joel Spratt
José M. Dias
Ana I. Teixeira
ResearchOpen Access09 Oct 2023
Nature Nanotechnology

Volume: 19, P: 237-245
Induction of p19INK4d in response to ultraviolet light improves DNA repair and confers resistance to apoptosis in neuroblastoma cells

Julieta M Ceruti
María E Scassa
Eduardo T Cánepa
Research07 Mar 2005
Oncogene

Volume: 24, P: 4065-4080
Temporal dynamics of the multi-omic response to endurance exercise training

Temporal multi-omic analysis of tissues from rats undergoing up to eight weeks of endurance exercise training reveals widespread shared, tissue-specific and sex-specific changes, including immune, metabolic, stress response and mitochondrial pathways.

David Amar
Nicole R. Gay
Elena Volpi
ResearchOpen Access01 May 2024
Nature

Volume: 629, P: 174-183
MNU Induction of Neoplasia in a Platyfish Model

Steven Kazianis
Irma Gimenez-Conti
Ronald B Walter
Research01 Sept 2001
Laboratory Investigation

Volume: 81, P: 1191-1198
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

In ischaemic tissues, hypoxia and nutrient deprivation were found to induce the transcriptional regulator PGC-1α which in turn induces VEGF to promote angiogenesis; this pathway is independent of hypoxia-inducible factor, which is also implicated in hypoxia-induced VEGF regulation and angiogenesis.

Zoltan Arany
Shi-Yin Foo
Bruce M. Spiegelman
Research21 Feb 2008
Nature

Volume: 451, P: 1008-1012
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

PPARγ ligands are used to control diabetes, but their anti-diabetic actions are puzzling. Here the authors show that phosphorylation of PPARγ by cyclin-dependent kinase 5 (Cdk5) in mice is linked to obesity induced by high-fat feeding, and that inhibition of the effect in humans by the drug rosiglitazone is closely associated with its anti-diabetic effects. Several anti-diabetic PPARγ ligands directly inhibit the effect, and thus support a more normal non-diabetic pattern of gene expression.

Jang Hyun Choi
Alexander S. Banks
Bruce M. Spiegelman
Research22 Jul 2010
Nature

Volume: 466, P: 451-456
Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice

Molecular diversity of proprioceptive neuron types (Ia, Ib and II PNs) is unclear. Here, the authors characterized the functional organization and development of eight subtypes of PNs in mice. Importantly, Ia subtypes are plastic, suggesting a role in adaptive proprioception during motor behavior.

Haohao Wu
Charles Petitpré
François Lallemend
ResearchOpen Access15 Feb 2021
Nature Communications

Volume: 12, P: 1-13
Thalamic volumetric abnormalities in type 1 diabetes mellitus and ‘peripheral’ neuropathy

João L. Novo
José J. Ruas
António José de Bastos-Leite
ResearchOpen Access29 Jul 2022
Scientific Reports

Volume: 12, P: 1-7
Role of p16/MTS1, cyclin D1 and RB in primary oral cancer and oral cancer cell lines

M Sartor
H Steingrimsdottir
M Tavassoli
ResearchOpen Access26 Mar 1999
British Journal of Cancer

Volume: 80, P: 79-86
The biogenic amines putrescine and cadaverine show in vitro cytotoxicity at concentrations that can be found in foods

Beatriz del Rio
Begoña Redruello
Miguel A. Alvarez
ResearchOpen Access15 Jan 2019
Scientific Reports

Volume: 9, P: 1-7
Genetic mapping of sex-linked markers in Salix viminalis L.

V Semerikov
U Lagercrantz
M Lascoux
Research26 Aug 2003
Heredity

Volume: 91, P: 293-299
Metabolic communication during exercise

Cellular metabolic demand skyrockets during intense exercise, thus rendering the communication of metabolic state essential for organismal homeostasis. Murphy, Watt and Febbraio discuss the physiological processes governing intertissue communication during exercise and the molecules mediating such cross-talk.

Robyn M. Murphy
Matthew J. Watt
Mark A. Febbraio
Reviews03 Aug 2020
Nature Metabolism

Volume: 2, P: 805-816
Repression of Dmp1 and Arf transcription by anthracyclins: critical roles of the NF-κB subunit p65

P Taneja
A Mallakin
K Inoue
Research04 Jun 2007
Oncogene

Volume: 26, P: 7457-7466
HRPT2, encoding parafibromin, is mutated in hyperparathyroidism–jaw tumor syndrome

J.D. Carpten
C.M. Robbins
M.R. Hobbs
Research18 Nov 2002
Nature Genetics

Volume: 32, P: 676-680
Loss of p19ARF enhances the defects of Mdm2 overexpression in the mammary gland

Carolyn J Foster
Guillermina Lozano
Research21 May 2002
Oncogene

Volume: 21, P: 3525-3531
Ink4c is dispensable for tumor suppression in Myc-induced B-cell lymphomagenesis

L M Nilsson
U B Keller
M F Roussel
Research13 Nov 2006
Oncogene

Volume: 26, P: 2833-2839
Different cooperating effect of p21 or p27 deficiency in combination with INK4a/ARF deletion in mice

Juan Martín-Caballero
Juana M Flores
Manuel Serrano
Research20 Sept 2004
Oncogene

Volume: 23, P: 8231-8237
Seed morphometrics unravels the evolutionary history of grapevine in France

L. Bouby
V. Bonhomme
J. F. Terral
ResearchOpen Access27 Sept 2024
Scientific Reports

Volume: 14, P: 1-15
Evolutionary DNA variation in the genus Hypochaeris

M Cerbah
J Coulaud
S Siljak-yakovlev
Research01 Mar 1999
Heredity

Volume: 82, P: 261-266
CpG island methylation in carcinoid and pancreatic endocrine tumors

Annie On-On Chan
Sang Geol Kim
Asif Rashid
Research13 Feb 2003
Oncogene

Volume: 22, P: 924-934
Histone deacetylase inhibitors activate INK4d gene through Sp1 site in its promoter

Tomoya Yokota
Youichirou Matsuzaki
Toshiyuki Sakai
Research26 Apr 2004
Oncogene

Volume: 23, P: 5340-5349
High level expression of ΔN-p63: a mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC)?

Tim Crook
John M Nicholls
Martin J Allday
Research17 Jul 2000
Oncogene

Volume: 19, P: 3439-3444
The status of CDKN2A alpha (p16^INK4A) and beta (p14^ARF) transcripts in thyroid tumour progression

A Ferru
G Fromont
L Karayan-Tapon
ResearchOpen Access21 Nov 2006
British Journal of Cancer

Volume: 95, P: 1670-1677
Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk

Miguel Moutinho
Maria João Nunes
Elsa Rodrigues
ResearchOpen Access05 Aug 2016
Scientific Reports

Volume: 6, P: 1-18
Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells

H Yasaei
E Gilham
R F Newbold
Research12 Mar 2012
Oncogene

Volume: 32, P: 171-179
Improved sampling and DNA extraction procedures for microbiome analysis in food-processing environments

This protocol describes a method for sampling the microbiome of food-processing facilities and analyzing it by using whole-metagenome sequencing. The protocol includes sampling and DNA-extraction and DNA-purification steps optimized for low-biomass samples.

Coral Barcenilla
José F. Cobo-Díaz
Avelino Alvarez-Ordóñez
Protocols24 Jan 2024
Nature Protocols

Volume: 19, P: 1291-1310
ARF antagonizes the ability of Miz-1 to inhibit p53-mediated transactivation

L Miao
Z Song
M Wu
Research09 Nov 2009
Oncogene

Volume: 29, P: 711-722
Expression of Dmp1 in specific differentiated, nonproliferating cells and its regulation by E2Fs

A Mallakin
P Taneja
K Inoue
Research31 Jul 2006
Oncogene

Volume: 25, P: 7703-7713
Phenotypic alterations in Rb pathway have more prognostic influence than p53 pathway proteins in oral carcinoma

R Jayasurya
K M Sathyan
S Kannan
Research25 Feb 2005
Modern Pathology

Volume: 18, P: 1056-1066
Chromosomal instability at a mutational hotspot in polyoma middle T-antigen affects its ability to activate the ARF-p53 tumor suppressor pathway

P Rodriguez-Viciana
C H Collins
M Fried
Research31 Oct 2005
Oncogene

Volume: 25, P: 1454-1462
Economic burden of breast cancer in India, 2000–2021 and forecast to 2030

Rakesh N Pillai
Aleena Alex
Denny John
ResearchOpen Access08 Jan 2025
Scientific Reports

Volume: 15, P: 1-11
Regulation and activation of p53 and its family members

M A E Lohrum
KH Vousden
Reviews13 Nov 1999
Cell Death & Differentiation

Volume: 6, P: 1162-1168
GRK3 deficiency elicits brain immune activation and psychosis

Carl M. Sellgren
Sophie Imbeault
Sophie Erhardt
ResearchOpen Access12 May 2021
Molecular Psychiatry

Volume: 26, P: 6820-6832
p16^Ink4a overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors

C Romagosa
S Simonetti
S Ramon y Cajal
Reviews07 Feb 2011
Oncogene

Volume: 30, P: 2087-2097

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