Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–11 of 11 results
Advanced filters: Author: M. William Lensch Clear advanced filters

  • An international survey of human embryonic stem cell lines provides a benchmark for comparing results across laboratories.

    • M William Lensch
    • George Q Daley
    News & Views
    Nature Biotechnology
    Volume: 25, P: 748-750

  • This paper reports the ability to isolate human donor biopsies and use transcription factors to derive induced Pluripotent Stem (iPS) cells from fetal, neonatal, and adult human primary cells, including dermal fibroblasts isolated from a skin biopsy of a healthy adult volunteer. The human iPS cells resembled embryonic stem cells in their morphology and gene expression. These data establish a method to isolate iPS cells from patients, suggesting that it may be possible to use this procedure to isolate patient-specific cells in culture.

    • In-Hyun Park
    • Rui Zhao
    • George Q. Daley
    Research
    Nature
    Volume: 451, P: 141-146

  • Individuals with Down's syndrome are known to have a lower rate of certain solid cancers. Now, a mouse model with one extra copy of Dscr1, a gene located on chromosome 21, is shown to display decreased tumour growth; this is thought to be via suppression of angiogenesis mediated by decreasing the activity of the calcineurin pathway.

    • Kwan-Hyuck Baek
    • Alexander Zaslavsky
    • Sandra Ryeom
    Research
    Nature
    Volume: 459, P: 1126-1130

  • Following initiation of the heartbeat in vertebrate embryos, cells lining the aorta, the placental vessels, and the umbilical and vitelline arteries begin to form haematopoietic cells. Here it is shown that biochemical forces imposed on the vascular wall at this developmental stage strongly influence development of early blood cells and that abrogation of nitric oxide—a mediator of shear-stress-induced signalling—compromises haematopoietic potential in vitro and in vivo.

    • Luigi Adamo
    • Olaia Naveiras
    • George Q. Daley
    Research
    Nature
    Volume: 459, P: 1131-1135

  • Thanks to improved functional assays and more effective protocols for directed tissue differentiation, pluripotent stem cells are proving increasingly useful for uncovering the genetic and epigenetic basis of monogenic and complex diseases, and for investigating the functional consequences of genetic variation.

    • Hao Zhu
    • M. William Lensch
    • George Q. Daley
    Reviews
    Nature Reviews Genetics
    Volume: 12, P: 266-275

  • In response to the need for a defined set of criteria to assess stem-cell potency, this review proposes guidelines for the evaluation of newly derived pluripotent stem cells, from functional assays to integrative molecular analyses of transcriptional, epigenetic and metabolic states.

    • Alejandro De Los Angeles
    • Francesco Ferrari
    • George Q. Daley
    Reviews
    Nature
    Volume: 525, P: 469-478