Nature Search

Molecular Genetic Changes in Metastatic Primary Barrett’s Adenocarcinoma and Related Lymph Node Metastases: Comparison with Nonmetastatic Barrett’s Adenocarcinoma

Axel K Walch
Horst F Zitzelsberger
Martin Werner
Research01 Jul 2000
Modern Pathology

Volume: 13, P: 814-824
Barrett's Esophagus and Barrett's-Related Dysplasia

John R Goldblum
Research01 Apr 2003
Modern Pathology

Volume: 16, P: 316-324
Utilization of Cytokeratins 7 and 20 Does Not Differentiate between Barrett's Esophagus and Gastric Cardiac Intestinal Metaplasia

I A Mohammed
C J Streutker
R H Riddell
Research01 Jun 2002
Modern Pathology

Volume: 15, P: 611-616
The Location and Frequency of Intestinal Metaplasia at the Esophagogastric Junction in 223 Consecutive Autopsies: Implications for Patient Treatment and Preventive Strategies in Barrett's Esophagus

Adrian H Ormsby
Sony P Kilgore
Terry L Gramlich
Research01 Jun 2000
Modern Pathology

Volume: 13, P: 614-620
p53 Gene Mutation and Protein Accumulation during Neoplastic Progression in Barrett's Esophagus

Yan-Song Bian
Maria-Chiara Osterheld
Charlotte Fontolliet
Research01 May 2001
Modern Pathology

Volume: 14, P: 397-403
Differential expression of Hsp27 in normal oesophagus, Barrett’s metaplasia and oesophageal adenocarcinomas

O S Soldes
R D Kuick
D G Beer
ResearchOpen Access14 Jan 1999
British Journal of Cancer

Volume: 79, P: 595-603
Retrovirus–mediated wild–type P53 gene transfer to tumors of patients with lung cancer.

J.A. Roth
D. Nguyen
D. Cai
Research01 Sept 1996
Nature Medicine

Volume: 2, P: 985-991
Correlation of Colour and Music

F. DE CHAUMONT
Research20 Jan 1870
Nature

Volume: 1, P: 314-315
Prevalence and Prognostic Significance of Neuroendocrine Cells in Esophageal Adenocarcinoma

Katherine Hamilton
Alberto Chiappori
Kay Washington
Research01 May 2000
Modern Pathology

Volume: 13, P: 475-481
No Demonstrable Long Term Effects of Cigarette Smoking on the Mucociliary Mechanism of the Human Lung

D. PAVIA
M. D. SHORT
M. L. THOMSON
Research27 Jun 1970
Nature

Volume: 226, P: 1228-1231
Structure of cytochrome c′: a dimeric, high-spin haem protein

Patricia C. Weber
R. G. Bartsch
F. R. Salemme
Research17 Jul 1980
Nature

Volume: 286, P: 302-304
Mutations in β-Catenin and APC Genes are Uncommon in Esophageal and Esophagogastric Junction Adenocarcinomas

Young W Choi
Elisabeth I Heath
Tsung-Teh Wu
Research01 Oct 2000
Modern Pathology

Volume: 13, P: 1055-1059
The role of microRNAs in cancers of the upper gastrointestinal tract

Upper gastrointestinal tract cancers (UGICs) pose a major health risk around the world, and therapeutic improvements have been very slow and small. Increased understanding of the role of microRNAs in UGICs could lead to novel prevention strategies, early detection and improved therapeutics for these cancers.

Shumei Song
Jaffer A. Ajani
Reviews20 Nov 2012
Nature Reviews Gastroenterology & Hepatology

Volume: 10, P: 109-118
Anisotropy of the Young's modulus of bone

W. BONFIELD
M. D. GRYNPAS
Research01 Dec 1977
Nature

Volume: 270, P: 453-454
Characterization of molecular defects in xeroderma pigmentosum group C

Lei Li
Elise S. Bales
Randy J. Legerski
Research01 Dec 1993
Nature Genetics

Volume: 5, P: 413-417
Changing the firing threshold for normal optic nerve axons by the application of infra-red laser light

Lavinia J. Austerschmidt
Nadine I. Schottler
Mark D. Baker
ResearchOpen Access15 Oct 2021
Scientific Reports

Volume: 11, P: 1-11
Expression cloning of a human DNA repair gene involved in xeroderma pigmentosum group C

Randy Legerski
Carolyn Peterson
Research03 Sept 1992
Nature

Volume: 359, P: 70-73
Mechanism of C-terminal amide formation by pituitary enzymes

A. F. Bradbury
M. D. A. Finnie
D. G. Smyth
Research12 Aug 1982
Nature

Volume: 298, P: 686-688
Gastric Dysplasia-Like Epithelial Atypia Associated with Chemoradiotherapy for Esophageal Cancer: A Clinicopathologic and Immunohistochemical Study of 15 Cases

Thomas P Brien
Francis A Farraye
Robert D Odze
Research01 May 2001
Modern Pathology

Volume: 14, P: 389-396
Cryptic suture in the eastern Grenville Province

M. D. THOMAS
J. G. TANNER
Research31 Jul 1975
Nature

Volume: 256, P: 392-394
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
The Injection of Cocaine as a Remedy for Stings

M.D. OXON
Research22 Sept 1898
Nature

Volume: 58, P: 497
Assessing intraepithelial neoplasia and drug safety in cancer-preventive drug development

Can the process of new cancer-preventive drug development be improved by focusing on precancer (intraepithelial neoplasia) to better identify subjects at risk and prove efficacy in shorter, smaller trials?

Gary J. Kelloff
Caroline C. Sigman
Reviews01 Jul 2007
Nature Reviews Cancer

Volume: 7, P: 508-518
Gastric Cardia Intestinal Metaplasia: Biopsy Follow-Up of 85 Patients

Neal S Goldstein
Research01 Oct 2000
Modern Pathology

Volume: 13, P: 1072-1079
Molecular targets for cancer chemoprevention

The field of cancer chemoprevention has reported its first major successes, but broad translation to the clinic is not yet a reality. Here, Lippman and colleagues review the unique challenges encountered in this field, and the promise of personalized, molecularly targeted chemoprevention strategies.

William N. William Jr
John V. Heymach
Scott M. Lippman
Reviews01 Mar 2009
Nature Reviews Drug Discovery

Volume: 8, P: 213-225
Optical imaging for screening and early cancer diagnosis in low-resource settings

The ability to detect precancer at the point of care is important to reduce global inequities in cancer outcomes. This Review outlines how low-cost optical imaging technologies, slide-free microscopy and machine learning can improve imaging performance and provide real-time interpretation in settings with limited resources.

Rebecca Richards-Kortum
Cesaltina Lorenzoni
Kathleen Schmeler
Reviews22 Dec 2023
Nature Reviews Bioengineering

Volume: 2, P: 25-43
Colonic crypt organization and tumorigenesis

Recent advances in our understanding of intestinal crypt biology, including how mutations in stem cells become fixed and expand within the epithelium, has led to new theories on the origins of colonic adenomas and cancers.

Adam Humphries
Nicholas A. Wright
Reviews15 May 2008
Nature Reviews Cancer

Volume: 8, P: 415-424
Systematic evaluation of an atomic clock at 2 × 10⁻¹⁸ total uncertainty

Atomic clocks are increasingly important for many applications in scientific research and technology. Here, Nicholson et al. present a series of developments allowing them to achieve a new record in atomic clock performance, with a systematic uncertainty of just 2.1 × 10⁻¹⁸ for their ⁸⁷Sr atomic clock.

T.L. Nicholson
S.L. Campbell
J. Ye
ResearchOpen Access21 Apr 2015
Nature Communications

Volume: 6, P: 1-8
Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148

Genetic variants at multiple loci of chr5p15.33 have been associated with susceptibility to numerous cancers. Here the authors show that the association of one of these loci may be explained by a variant, rs36115365, influencing telomerase reverse transcriptase (TERT) expression via ZNF148.

Jun Fang
Jinping Jia
Laufey T. Amundadottir
ResearchOpen Access27 Apr 2017
Nature Communications

Volume: 8, P: 1-17
Mutations at the mitochondrial DNA polymerase (POLG) locus associated with male infertility

Anja T. Rovio
David R. Marchington
Howard T. Jacobs
Research22 Oct 2001
Nature Genetics

Volume: 29, P: 261-262
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Prism adaptation for spatial neglect after stroke: translational practice gaps

Around half of all stroke survivors exhibit spatial neglect—a failure to report, respond to or orientate to contralesional stimuli. Current therapeutic approaches for spatial neglect focus largely on visual perceptual processing, but many patients respond poorly to such approaches because their main impairments lie in spatial motor 'aiming' function. Here, Barrett et al. highlight a promising alternative approach—prism adaptation treatment—that specifically targets spatial motor deficits.

A. M. Barrett
Kelly M. Goedert
Julia C. Basso
Reviews28 Aug 2012
Nature Reviews Neurology

Volume: 8, P: 567-577
Cancer as an evolutionary and ecological process

Neoplasms are microcosms of evolution. The evolution of neoplastic cells explains why we get cancer and why it has been so difficult to cure. Can evolutionary biology provide new insights into the clinical control of cancer?

Lauren M.F. Merlo
John W. Pepper
Carlo C. Maley
Reviews16 Nov 2006
Nature Reviews Cancer

Volume: 6, P: 924-935
Future directions in cancer prevention

Based on previous successes and failures, this Review discusses potential future directions for cancer prevention that include the use of genetic, proteomic and other molecular approaches to identify pathways that could be modified during cancer initiation. The use of immunotherapies for cancer prevention is also discussed.

Asad Umar
Barbara K. Dunn
Peter Greenwald
Reviews15 Nov 2012
Nature Reviews Cancer

Volume: 12, P: 835-848
Analysis of acquired resistance mechanisms to osimertinib in patients with EGFR-mutated advanced non-small cell lung cancer from the AURA3 trial

In the phase III AURA3 study (NCT02151981), the third-generation epidermal growth factor receptor tyrosine kinase inhibitor osimertinib prolonged progression-free survival versus platinum-doublet chemotherapy in patients with EGFR T790M advanced NSCLC. Here, by next-generation sequencing of circulating tumor DNA, the authors assess candidate mechanisms of acquired resistance to osimertinib in patients from the AURA3 trial.

Juliann Chmielecki
Tony Mok
Vassiliki Papadimitrakopoulou
ResearchOpen Access27 Feb 2023
Nature Communications

Volume: 14, P: 1-8
Cellular senescence in gastrointestinal diseases: from pathogenesis to therapeutics

Cellular senescence is induced in response to various stresses and can either prevent or fuel disease and tumorigenesis. Here, the authors provide an overview of senescence aimed at gastroenterologists and hepatologists and detail how modulation of senescence might be used for therapeutic purposes.

Nina Frey
Sascha Venturelli
Michael Bitzer
Reviews29 Nov 2017
Nature Reviews Gastroenterology & Hepatology

Volume: 15, P: 81-95
Realization of quantum error correction

J. Chiaverini
D. Leibfried
D. J. Wineland
Research02 Dec 2004
Nature

Volume: 432, P: 602-605
Deterministic quantum teleportation of atomic qubits

M. D. Barrett
J. Chiaverini
D. J. Wineland
Research17 Jun 2004
Nature

Volume: 429, P: 737-739
Genome-wide association study identifies three new melanoma susceptibility loci

Timothy Bishop and colleagues of the GenoMEL Consortium report a genome-wide association study for melanoma, identifying three new susceptibility loci.

Jennifer H Barrett
Mark M Iles
D Timothy Bishop
Research09 Oct 2011
Nature Genetics

Volume: 43, P: 1108-1113
From polyploidy to aneuploidy, genome instability and cancer

Zuzana Storchova
David Pellman
Reviews01 Jan 2004
Nature Reviews Molecular Cell Biology

Volume: 5, P: 45-54
Cancer prevention by targeting angiogenesis

The association between cancer and angiogenesis has been established for decades, but it is only in the past 10 years that the concept of cancer prevention using antiangiogenic agents has emerged. This Review outlines the mechanisms of action of these preventative agents and proposes that there should be four levels of angioprevention, depending on the cancer risk.

Adriana Albini
Francesca Tosetti
William W. Li
Reviews31 Jul 2012
Nature Reviews Clinical Oncology

Volume: 9, P: 498-509
Malignant Islet Cell Tumor with Sarcomatous Differentiation

Lyska Emerson
Lester J Layfield
Joseph Holden
Research01 Nov 2001
Modern Pathology

Volume: 14, P: 1187-1191
Buprenorphine Reduces Cerebral Glucose Metabolism in Polydrug Abusers

Sharon L. Walsh
Stephen F. Gilson
Edythe D. London
Research01 May 1994
Neuropsychopharmacology

Volume: 10, P: 157-170
Mining the Wnt pathway for cancer therapeutics

The Wnt signalling pathway has a central role in tissue development and tissue maintenance, but is frequently dysregulated in several types of cancer, particularly those of the digestive tract. Here, Barker and Clevers examine the recent progress in the development of Wnt inhibitors as anticancer drugs.

Nick Barker
Hans Clevers
Reviews01 Dec 2006
Nature Reviews Drug Discovery

Volume: 5, P: 997-1014
Clinical proteomics: translating benchside promise into bedside reality

Emanuel F. Petricoin
Kathryn C. Zoon
Lance A. Liotta
Reviews01 Sept 2002
Nature Reviews Drug Discovery

Volume: 1, P: 683-695
Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

Impaired TGF-β signaling due to SMAD4 mutation in PDAC tumors initiates a STAT3-dependent signaling cascade that leads to increased stromal stiffening and disease progression.

Hanane Laklai
Yekaterina A Miroshnikova
Valerie M Weaver
Research18 Apr 2016
Nature Medicine

Volume: 22, P: 497-505
Author Correction: Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

Hanane Laklai
Yekaterina A. Miroshnikova
Valerie M. Weaver
Amendments and Corrections28 Nov 2023
Nature Medicine

Volume: 30, P: 908
TRANSIENT HYPERAMMONEMIA OF THE NEWBORN (THAN) AND UREA CYCLE ENZYME DEFECTS (UCED) DIFFERENTIATED BY CLINICAL PRESENTATION

M L Hudak
M D Jones Jr.
S Busilow
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 328
Overlap of functional dyspepsia and GERD—diagnostic and treatment implications

Although GERD and functional dyspepsia are generally thought of as completely distinct disorders with unique symptoms and treatments, they are, in many ways, more similar than different and can overlap in the same individual. This Review, which focuses on the overlap of GERD with functional dyspepsia, describes similarities and differences with regards to the epidemiology, pathophysiology, diagnosis and treatment of these two disorders.

Eamonn M. M. Quigley
Brian E. Lacy
Reviews08 Jan 2013
Nature Reviews Gastroenterology & Hepatology

Volume: 10, P: 175-186
Testing guidelines for hereditary non-polyposis colorectal cancer

Asad Umar
John I. Risinger
J. Carl Barrett
Reviews01 Feb 2004
Nature Reviews Cancer

Volume: 4, P: 153-158

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