A combination of equilibrium amide exchange and kinetic folding data show that the essential features of the complex topology of the N-terminal domain of a thermophilic phosphoglycerate kinase are established on a millisecond or faster timescale, before the rate-limiting step in the folding pathway commences.
- Laszlo L. P. Hosszu
- C. Jeremy Craven
- Jonathan P. Waltho
