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European Journal of Human Genetics (1)
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Advanced filters: Author: Maarten van Dinther Clear advanced filters

TGM6 is a helminth secretory product that mimics TGF-β binding to TGFBR2 to antagonize signaling in fibroblasts

The parasitic helminth H. polygyrus secretes modular TGF-β mimic proteins to dampen host immunity. Here, the authors show H. polygyrus secretes a related protein which inhibits TGF-β signaling in fibroblasts to minimize fibrotic damage to the host.

Stephen E. White
Tristin A. Schwartze
Andrew P. Hinck
ResearchOpen Access21 Feb 2025
Nature Communications

Volume: 16, P: 1-15
ALK2 mutation in a patient with Down's syndrome and a congenital heart defect

Irene C Joziasse
Kelly A Smith
Jeroen Bakkers
Research19 Jan 2011
European Journal of Human Genetics

Volume: 19, P: 389-393

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TGM6 is a helminth secretory product that mimics TGF-β binding to TGFBR2 to antagonize signaling in fibroblasts

ALK2 mutation in a patient with Down's syndrome and a congenital heart defect

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