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Advanced filters: Author: Mackenzie Edmondson Clear advanced filters

Pembrolizumab for advanced urothelial carcinoma: exploratory ctDNA biomarker analyses of the KEYNOTE-361 phase 3 trial

In an exploratory analysis of the KEYNOTE-361 phase 3 trial that tested immunotherapy and chemotherapy in advanced urothelial carcinoma, different early circulating tumor DNA (ctDNA) dynamics were observed between the two treatments, and ctDNA levels were associated with response to pembrolizumab but not to chemotherapy.

Thomas Powles
Yen-Hwa Chang
Seyda Gunduz
ResearchOpen Access01 Jun 2024
Nature Medicine

Volume: 30, P: 2508-2516
DLMM as a lossless one-shot algorithm for collaborative multi-site distributed linear mixed models

A lossless, one-shot and privacy-preserving distributed algorithm was revealed for fitting linear mixed models on multi-site data. The algorithm was applied to a study of 120,609 COVID-19 patients using only minimal aggregated data from each of 14 sites.

Chongliang Luo
Md. Nazmul Islam
Yong Chen
ResearchOpen Access30 Mar 2022
Nature Communications

Volume: 13, P: 1-10
Distributed learning for heterogeneous clinical data with application to integrating COVID-19 data across 230 sites

Jiayi Tong
Chongliang Luo
Yong Chen
ResearchOpen Access14 Jun 2022
npj Digital Medicine

Volume: 5, P: 1-8
An efficient and accurate distributed learning algorithm for modeling multi-site zero-inflated count outcomes

Mackenzie J. Edmondson
Chongliang Luo
Yong Chen
ResearchOpen Access04 Oct 2021
Scientific Reports

Volume: 11, P: 1-17

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