This study uses somatic mutations as a natural barcoding system to retrospectively and prospectively trace the fate of hematopoietic stem cells across all major blood cell lineages in healthy aged individuals. It reveals the existence of intrinsically fate-biased hematopoietic stem cells in native human hematopoiesis, validated by transplantation assays.
- Tetsuichi Yoshizato
- Christer Nilsson
- Sten Eirik W. Jacobsen
