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Showing 1–7 of 7 results
Advanced filters: Author: Madeleine Wyss Clear advanced filters

  • Histone H1 binds to nucleosomes with ultrahigh affinity, implying residence times incompatible with efficient biological regulation. Now it has been shown that the disordered regions of H1 retain their large-amplitude dynamics on the nucleosome, which enables a charged disordered histone chaperone to invade the H1–nucleosome complex and vastly accelerate H1 dissociation.

    • Pétur O. Heidarsson
    • Davide Mercadante
    • Benjamin Schuler
    Research
    Nature Chemistry
    Volume: 14, P: 224-231

  • Artificial intelligence is revolutionizing protein design by enabling precise navigation of sequence space and accelerating the creation of functional proteins. In this Review, a practical roadmap guides integration of artificial intelligence tools into design workflows, highlighting structural prediction, generative models and case studies spanning engineering therapeutic proteins to designing new ones.

    • Huan Yee Koh
    • Yizhen Zheng
    • George M. Church
    Reviews
    Nature Reviews Bioengineering
    Volume: 3, P: 1034-1056

  • The inner layer of the mucus that covers our intestine is nearly sterile. Here, the authors show in mice that the outer mucus layer constitutes a unique microbial niche hosting bacterial communities with distinct proliferation rates and resource utilization activities.

    • Hai Li
    • Julien P. Limenitakis
    • Andrew J. Macpherson
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13

  • A new DNA analysis method termed long fragment read technology is described, and the approach is used to determine parental haplotypes and to sequence human genomes cost-effectively and accurately from only 10 to 20 cells.

    • Brock A. Peters
    • Bahram G. Kermani
    • Radoje Drmanac
    ResearchOpen Access
    Nature
    Volume: 487, P: 190-195