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Showing 1–5 of 5 results
Advanced filters: Author: Madeline R. Luth Clear advanced filters

  • The ability to evolve Plasmodium drug resistance in vitro is challenging and time consuming. Here, Kümpornsin et al. generated a Plasmodium falciparum parasite line with an elevated mutation rate by impairing the proof-reading activity of DNA polymerase, which results in a higher mutation rate, quick resistance development, and a lower inoculum than wild type to support the identification of new antimalarial targets and understand drug resistance mechanisms.

    • Krittikorn Kümpornsin
    • Theerarat Kochakarn
    • Marcus C. S. Lee
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • New antimalarials are urgently needed. Here, the authors identify Open Source Malaria compound, OSMS-106, as a reaction hijacking inhibitor of the malaria parasite protein synthesis machinery, with potential use for treatment and prophylaxis.

    • Stanley C. Xie
    • Yinuo Wang
    • Leann Tilley
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • The development of antimalarials against the human liver and asexual blood stages is one of the top public health challenges. Here, the authors report a single-step biochemical assay for the characterization of prolyl-tRNA synthetase inhibitors, and develop high-affinity inhibitors for the enzyme, including elusive triple-site ligands.

    • Mark A. Tye
    • N. Connor Payne
    • Ralph Mazitschek
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • Ottilie et al. employ an experimental evolution approach to investigate the role of transcription factors in yeast chemical resistance. Most emergent mutations in resistant strains were enriched in transcription factor coding genes, highlighting their importance in drug resistance.

    • Sabine Ottilie
    • Madeline R. Luth
    • Elizabeth A. Winzeler
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-14