Nature Search

Publisher Correction: Shared proteomic effects of cerebral atherosclerosis and Alzheimer’s disease on the human brain

Aliza P. Wingo
Wen Fan
Thomas S. Wingo
Amendments and Corrections23 Jun 2020
Nature Neuroscience

Volume: 23, P: 1034
Plasma p-tau212 antemortem diagnostic performance and prediction of autopsy verification of Alzheimer’s disease neuropathology

A range of blood-based biomarkers have shown high specificity for Alzheimer’s disease (AD) pathophysiology with phosphorylated-tau (p-tau) being the most promising test. Here, the authors show the utility of plasma p-tau212 in autopsy-confirmed AD and memory clinic patient cohorts.

Przemysław R. Kac
Fernando González-Ortiz
Thomas K. Karikari
ResearchOpen Access23 Mar 2024
Nature Communications

Volume: 15, P: 1-16
Sex differences in brain protein expression and disease

Analyses of 1,277 human brain proteomes reveal the extent of sex differences in the brain and identify genes associated with neuropsychiatric traits that have differential regulation between males and females.

Aliza P. Wingo
Yue Liu
Thomas S. Wingo
ResearchOpen Access31 Aug 2023
Nature Medicine

Volume: 29, P: 2224-2232
A multicentre validation study of the diagnostic value of plasma neurofilament light

Cerebrospinal fluid neurofilament light (NfL) is a biomarker for neurodegeneration that can also be assessed in blood. Here the authors show in a validation study the potential for plasma NfL as a biomarker for several neurodegenerative diseases.

Nicholas J. Ashton
Shorena Janelidze
Oskar Hansson
ResearchOpen Access07 Jun 2021
Nature Communications

Volume: 12, P: 1-12
Lecanemab trial in AD brings hope but requires greater clarity

The phase III Clarity AD clinical trial of lecanemab, an amyloid-targeting antibody, showed a small clinical benefit in people with Alzheimer disease. However, several questions remain regarding the true clinical relevance, safety and accessibility of lecanemab in this patient population.

Madhav Thambisetty
Robert Howard
News & Views06 Jan 2023
Nature Reviews Neurology

Volume: 19, P: 132-133
Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age

Cognitive abilities tend to decline over time in advanced age, yet some individuals experience stable abilities or rapid decline. Here the authors present a proteome-wide association study of cognitive trajectory, and identify 38 proteins associated with cognitive resilience.

Aliza P. Wingo
Eric B. Dammer
Thomas S. Wingo
ResearchOpen Access08 Apr 2019
Nature Communications

Volume: 10, P: 1-14
Shared proteomic effects of cerebral atherosclerosis and Alzheimer’s disease on the human brain

Proteome-wide association studies of brain samples from older adults revealed effects of cerebral atherosclerosis and Alzheimer’s disease. A subset of proteins and protein co-expression modules were associated with both, suggesting shared mechanisms.

Aliza P. Wingo
Wen Fan
Thomas S. Wingo
Research18 May 2020
Nature Neuroscience

Volume: 23, P: 696-700
Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

Large-scale, comprehensive proteomic profiling of Alzheimer’s disease brain and cerebrospinal fluid reveals disease-associated protein coexpression modules and highlights the importance of glia and energy metabolism in disease pathogenesis.

Erik C. B. Johnson
Eric B. Dammer
Nicholas T. Seyfried
Research13 Apr 2020
Nature Medicine

Volume: 26, P: 769-780
Hydroxychloroquine lowers Alzheimer’s disease and related dementias risk and rescues molecular phenotypes related to Alzheimer’s disease

Vijay R. Varma
Rishi J. Desai
Madhav Thambisetty
ResearchOpen Access28 Dec 2022
Molecular Psychiatry

Volume: 28, P: 1312-1326
Unbiased proteomics and multivariable regularized regression techniques identify SMOC1, NOG, APCS, and NTN1 in an Alzheimer’s disease brain proteomic signature

Jackson A. Roberts
Vijay R. Varma
Madhav Thambisetty
ResearchOpen Access06 Jul 2023
npj Aging

Volume: 9, P: 1-10
Abnormal brain cholesterol homeostasis in Alzheimer’s disease—a targeted metabolomic and transcriptomic study

Vijay R. Varma
H. Büşra Lüleci
Madhav Thambisetty
ResearchOpen Access01 Jun 2021
npj Aging and Mechanisms of Disease

Volume: 7, P: 1-14

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