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Showing 1–2 of 2 results
Advanced filters: Author: Maeran Uhm Clear advanced filters

  • The drug amlexanox is known to improve obesity-related metabolic dysfunction in mice. Here the authors show that this effect is mediated by interleukin-6 secreted from subcutaneous adipocytes, which then inhibits gluconeogenesis in the liver by phosphorylating the hepatic transcription factor Stat3.

    • Shannon M. Reilly
    • Maryam Ahmadian
    • Alan R. Saltiel
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-12

  • Alan Saltiel and his colleagues report that the approved drug amlexanox, currently used to treat asthma and canker sores, is a relatively specific inhibitor of the noncanonical IκB kinases IKK-ɛ and TANK-binding kinase 1 (TBK1) and that it improves metabolic disease in mouse genetic and dietary models of obesity. These results suggest this drug may be repurposed to treat obesity and insulin resistance.

    • Shannon M Reilly
    • Shian-Huey Chiang
    • Alan R Saltiel
    Research
    Nature Medicine
    Volume: 19, P: 313-321