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Showing 1–2 of 2 results
Advanced filters: Author: Magali Joffraud Clear advanced filters

  • Nicotinamide adenine dinucleotide (NAD+) sustains cellular energy metabolism, functions as a substrate of Sirt and PARP enzymes, and its supplementation is explored therapeutically in aging and other contexts. Here the authors provide insight into the role of endogenous NAD+ metabolism by studying nicotinamide riboside kinase 1 (NRK1) deficient mice.

    • Audrey Sambeat
    • Joanna Ratajczak
    • Carles Canto
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Raising cellular levels of the metabolic cofactor NAD+ reverses key indicators of aging. Here, Ratajczak et al. show that cellular levels of NAD+ depend on the extracellular catalytic activity of NRK1, which processes two NAD+precursors, nicotinamide mononucleotide and nicotinamide riboside, in mice.

    • Joanna Ratajczak
    • Magali Joffraud
    • Carles Cantó
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12