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Advanced filters: Author: Magda Bahcall Clear advanced filters

Silent mutations reveal therapeutic vulnerability in RAS Q61 cancers

A translationally silent KRAS^G60G mutation, preventing the formation of a cryptic splice donor site and enabling expression of KRAS(Q61K), reveals a vulnerability in RAS^Q61 cancers that are therapeutically exploitable in a mutant-selective manner.

Yoshihisa Kobayashi
Chhayheng Chhoeu
Pasi A. Jänne
Research02 Mar 2022
Nature

Volume: 603, P: 335-342
An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer

Jänne and colleagues discover and characterize an allosteric EGFR inhibitor with efficacy against therapy-resistant mutations and show preclinical efficacy as monotherapy and in combination in patient-derived xenograft models.

Ciric To
Tyler S. Beyett
Pasi A. Jänne
Research14 Apr 2022
Nature Cancer

Volume: 3, P: 402-417

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Silent mutations reveal therapeutic vulnerability in RAS Q61 cancers

An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer

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