Nature Search

In silico docking yields small molecule negative allosteric modulators targeting the core of Frizzled 7

Although FZDs are promising drug targets, so far no small molecules targeting them were described. Here, the authors report the a FZD7 core-targeting small molecule negative allosteric modulators of WNT-induced signaling, confirmed by pharmacology, structure determination and MD simulations.

Magdalena M. Scharf
Julia Kinsolving
Gunnar Schulte
ResearchOpen Access14 Dec 2025
Nature Communications

Volume: 16, P: 1-15
Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder

Genome-wide analyses identify 30 independent loci associated with obsessive–compulsive disorder, highlighting genetic overlap with other psychiatric disorders and implicating putative effector genes and cell types contributing to its etiology.

Nora I. Strom
Zachary F. Gerring
Manuel Mattheisen
ResearchOpen Access13 May 2025
Nature Genetics

Volume: 57, P: 1389-1401
Structural basis of frizzled 7 activation and allosteric regulation

FZD₇ is a class F GPCR involved in intestinal epithelium homeostasis. Using cryo-EM, the authors determine the structure of inactive FZD₇ and compare it with the G-protein-bound form. They refine the FZD activation mechanisms and identify a water pocket and an allosteric cholesterol binding site.

Julien Bous
Julia Kinsolving
Gunnar Schulte
ResearchOpen Access28 Aug 2024
Nature Communications

Volume: 15, P: 1-15
Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations

Signaling pathway selectivity downstream of GPCRs is not fully understood. Here, authors perform functional analysis of Frizzled mutants to uncover state-stabilizing residues or ‘micro-switches’ mediating selectivity towards Disheveled over G proteins.

Lukas Grätz
Maria Kowalski-Jahn
Gunnar Schulte
ResearchOpen Access29 Jul 2023
Nature Communications

Volume: 14, P: 1-17
Influence of nitrogen fertilization, seed inoculation and the synergistic effect of these treatments on soybean yields under conditions in south-western Poland

Magdalena Serafin-Andrzejewska
Anna Jama-Rodzeńska
Andrzej Kotecki
ResearchOpen Access20 Mar 2024
Scientific Reports

Volume: 14, P: 1-11

Quick links

Search

Filter By:

In silico docking yields small molecule negative allosteric modulators targeting the core of Frizzled 7

Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder

Structural basis of frizzled 7 activation and allosteric regulation

Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations

Influence of nitrogen fertilization, seed inoculation and the synergistic effect of these treatments on soybean yields under conditions in south-western Poland

Search

Quick links