Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–20 of 20 results
Advanced filters: Author: Mahdi Moqri Clear advanced filters

  • Integration of gene expression data from multiple tissues across four mammalian species reveals conserved transcriptomic signatures of mammalian ageing and mortality and uncovers the modular architecture of ageing and mortality hallmarks.

    • Alexander Tyshkovskiy
    • Daria Kholdina
    • Vadim N. Gladyshev
    ResearchOpen Access
    Nature
    P: 1-16

  • At single-cell resolution, Tarkhov et al. delineate stochastic and co-regulated components of epigenetic aging, revealing a simultaneous loss of regulation at the epigenetic and transcriptional levels in aging.

    • Andrei E. Tarkhov
    • Thomas Lindstrom-Vautrin
    • Vadim N. Gladyshev
    Research
    Nature Aging
    Volume: 4, P: 854-870

  • DNA methylation (DNAm) is a key biomarker of aging, with age-related DNAm changes being well-characterized. Here, the authors show that low-methylated regions (LMRs) bound by PRC2 in embryonic stem cells gain methylation with age in somatic cells, proposing the “PRC2-AgeIndex” as a universal biomarker of cellular aging.

    • Mahdi Moqri
    • Andrea Cipriano
    • Vittorio Sebastiano
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • Epigenetic clocks estimate biological age and health risks. Here, the authors compare 14 clocks in 18,859 individuals, showing second-generation clocks better predict disease incidence and mortality, particularly for respiratory and liver-related conditions.

    • Christos Mavrommatis
    • Daniel W. Belsky
    • Riccardo E. Marioni
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-7

  • Ying, Paulson and collagues have developed an open-source framework, Biolearn, to harmonize and systematically evaluate 39 aging biomarkers across diverse populations, enabling standardized validation and facilitating development of robust aging biomarkers.

    • Kejun Ying
    • Seth Paulson
    • Vadim N. Gladyshev
    Research
    Nature Aging
    Volume: 5, P: 2323-2339

  • Previous studies have identified common genetic variants linked to longevity, but the impact of rare damaging mutations remains unclear. Here, the authors show that centenarians carry fewer harmful loss-of-function mutations and identify genes that may contribute to extreme longevity and healthy aging

    • Kejun Ying
    • José P. Castro
    • Vadim N. Gladyshev
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • The authors identify causality-enriched CpGs linked to aging using Mendelian randomization. They develop new epigenetic clocks, DamAge and AdaptAge, that more reliably track age-related changes, offering insights into aging mechanisms and interventions.

    • Kejun Ying
    • Hanna Liu
    • Vadim N. Gladyshev
    Research
    Nature Aging
    Volume: 4, P: 231-246

  • On 1–2 November 2024, the annual Biomarkers of Aging conference welcomed academic and industry scientists, and partners from governmental and nongovernmental organizations, to Harvard Medical School in Boston, USA, to discuss new insights into measuring and monitoring human aging, with the aim of clinical translation. In this Meeting Report, we summarize the conference and offer potential future directions for the Biomarkers of Aging Consortium and the longevity science community at large.

    • Erik Jacques
    • Chiara Herzog
    • Vadim N. Gladyshev
    News & Views
    Nature Aging
    Volume: 5, P: 539-543

  • Although the emerging field of geroscience holds great promise for identifying new approaches to improve healthspan, several risks of the current framework are underappreciated. Long time horizons, challenges in identifying causality-driven surrogate biomarkers of aging, and the potential for biological trade-offs and antagonistic effects across various timescales mean it will be hard to know when such interventions have a net benefit. We propose eight strategies to mitigate these risks going forwards.

    • Alan A. Cohen
    • John R. Beard
    • Martin Picard
    Comments & Opinion
    Nature Aging
    Volume: 5, P: 4-8

  • Robust validation of biomarkers of aging will be critical to their clinical translation; here, authors review the key challenges and propose recommendations to overcome them.

    • Mahdi Moqri
    • Chiara Herzog
    • Luigi Ferrucci
    Reviews
    Nature Medicine
    Volume: 30, P: 360-372

  • Cipriano et al. review recent progress in using epigenetic reprogramming to combat age-related deterioration at the cellular, tissue and organismal level, discussing reprogramming strategies and mechanisms, as well as remaining challenges in the field.

    • Andrea Cipriano
    • Mahdi Moqri
    • Vittorio Sebastiano
    Reviews
    Nature Aging
    Volume: 4, P: 14-26

  • Biomarkers of aging have potential to accelerate the clinical translation of interventions that promote healthy aging but are currently limited to research. The authors identify six barriers to be overcome to enable biomarker translation, providing a roadmap to clinical implementation.

    • Chiara M. S. Herzog
    • Ludger J. E. Goeminne
    • Vadim N. Gladyshev
    Reviews
    Nature Aging
    Volume: 4, P: 1372-1383