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Showing 1–3 of 3 results
Advanced filters: Author: Mahmut Parlak Clear advanced filters

  • CRISPR-Cas9 has been used to image repetitive loci in live cells to explore genome organization. Here the authors demonstrate the imaging of low-repeat regions with a single-guide RNA and the imaging of a non-repetitive region, allowing the tracking of transcriptionally active and inactive regions.

    • Peiwu Qin
    • Mahmut Parlak
    • Mazhar Adli
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • Pannexin 1 (PANX1) is a membrane channel mediating release of signaling molecules to the extracellular space. PANX1 can be activated by GPCRs. Here, the authors elucidate a non-canonical channel activation pathway by α1-adrenergic receptor that involves HDAC6- mediated lysine deacetylation of PANX1.

    • Yu-Hsin Chiu
    • Christopher B. Medina
    • Douglas A. Bayliss
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Early STOP codons created with CRISPR base editors leads to gene knockout with high efficiency and does not stress cells with double-strand DNA breaks. CRISPR-STOP can target the majority of human genes and is useful for genetic screens.

    • Cem Kuscu
    • Mahmut Parlak
    • Mazhar Adli
    Research
    Nature Methods
    Volume: 14, P: 710-712