Secondary lymphedema occurs frequently following oncologic surgery, but treatments are still lacking. Here the authors show, using both human samples and mouse models, that anti-CTLA4 mAb helps prevent edema and preserve lymphatic functions with corresponding expansion of Treg cells, thereby hinting anti-CTLA4 as a potential treatment option.
- Stefan Wolf
- Matiar Madanchi
- Epameinondas Gousopoulos
