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Showing 1–21 of 21 results
Advanced filters: Author: Maite Huarte Clear advanced filters

  • Maite Huarte discusses our current understanding of the impact of long noncoding RNAs on tumor growth and progression, and how this knowledge might be translated into new therapeutic approaches.

    • Maite Huarte
    Reviews
    Nature Medicine
    Volume: 21, P: 1253-1261

    • Maite Huarte
    Research Highlights
    Nature
    Volume: 459, P: 487

  • RNA modifications have emerged as key gene regulators. A new study shows that increased levels of reactive oxygen species in cancer induce widespread, sequence-specific modifications of guanines in the seed regions of microRNAs, altering the targets of those miRNAs and influencing tumorigenesis.

    • Marta Montes
    • Maite Huarte
    News & Views
    Nature Cell Biology
    Volume: 25, P: 1243-1244

  • Stabilization of p53 protein is a key step in the cellular response to DNA damage. A new study describes a long noncoding RNA, DINO, transcribed from the CDKN1A promoter region that induces stabilization of p53 protein and promotes efficient activation of p53 target genes in response to DNA damage.

    • Maite Huarte
    News & Views
    Nature Genetics
    Volume: 48, P: 1298-1299

  • SWI/SNF complexes regulate chromatin architecture and gene expression. Here the authors report the RNA interactome of SMARCB1-containing SWI/SNF complexes, showing the function of SMARCB1-interacting long noncoding RNA SWINGN in transcriptional activation of GAS6 and a set of SWI/SNF target genes.

    • Elena Grossi
    • Ivan Raimondi
    • Maite Huarte
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • The inaccurate annotation of long noncoding RNAs (lncRNAs) hampers their detection by scRNA-seq. The computational workflow ELATUS, based on the pseudoaligner Kallisto, addresses this problem and uncovers functional lncRNAs, such as AL121895.1, that participates in breast cancer.

    • Enrique Goñi
    • Aina Maria Mas
    • Mikel Hernaez
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Replication stress represents a major threat to genome integrity of normal and cancer cells. Here, the authors find that the long non-coding RNA lncREST affects the replication stress response through interaction with nucleolin. This interaction bridges the recruitment of replication factors to stressed chromatin.

    • Luisa Statello
    • José Miguel Fernandez-Justel
    • Maite Huarte
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Several studies have shown that p53 regulates the expression of some long noncoding RNAs (lncRNAs) implicated in apoptosis and proliferation. Here, by integrating RNA-seq and ChIP-seq analyses, the authors identify p53-regulated lncRNAs in the HCT116 colorectal cancer cell line.

    • Yolanda Sánchez
    • Victor Segura
    • Maite Huarte
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-13

  • A coordinated DNA damage response mediated by p53 to repair DNA lesions or to promote apoptosis is essential for maintenance of genome stability. A study now unveils the long non-coding RNA GUARDIN as a component of this pathway, which protects genome integrity in a pleiotropic fashion.

    • Elena Grossi
    • Maite Huarte
    News & Views
    Nature Cell Biology
    Volume: 20, P: 371-372

  • Two recent studies show that 'silent' variants can modulate regulatory circuits, including those in noncoding RNAs, affecting cancer predisposition and drug sensitivity.

    • Ivan Raimondi
    • Maite Huarte
    News & Views
    Nature Medicine
    Volume: 23, P: 1122-1123

  • PHF8 is a JmjC domain-containing protein, the gene for which has been linked to X-linked mental retardation (XLMR). These authors demonstrate PHF8 to be a histone demethylase with activity against H4K20me1. It has a role in regulating gene expression as well as in neuronal cell survival and craniofacial development in zebrafish. The results suggest there may be a link between histone methylation dynamics and XLMR.

    • Hank H. Qi
    • Madathia Sarkissian
    • Yang Shi
    Research
    Nature
    Volume: 466, P: 503-507

  • This study uses chromatin marks in four mouse cell types to identify ∼1,600 large multi-exonic transcriptional units that do not overlap known protein-coding loci and are highly conserved. Putative functions are assigned to each of these large intervening non-coding RNAs, which range from ES pluripotency to cell proliferation.

    • Mitchell Guttman
    • Ido Amit
    • Eric S. Lander
    Research
    Nature
    Volume: 458, P: 223-227

  • This Consensus Statement addresses the definition, nomenclature and classification of long non-coding RNAs, and provides a shared viewpoint on their features and functions. The authors also discuss research challenges and provide recommendations to advance our understanding of long non-coding RNAs.

    • John S. Mattick
    • Paulo P. Amaral
    • Mian Wu
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 24, P: 430-447

  • Recent studies have provided novel insight into the biogenesis of long non-coding RNAs (lncRNAs) and their specific functions. The functions of lncRNAs vary from transcriptional and post-transcriptional gene regulation to the assembly and function of membraneless nuclear bodies, and are relevant to neuronal disorders, immune responses and cancer.

    • Luisa Statello
    • Chun-Jie Guo
    • Maite Huarte
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 22, P: 96-118

  • In a recent paper published in Nature, Carrieri et al. have identified in mouse a neuron-specific antisense lncRNA transcribed in the opposite strand of Uchl1 mRNA. Antisense Uchl1 specifically promotes the translation of UCHL1 under rapamycin treatment. To do so, the lncRNA only requires a SINEB2 repeat and a small region with sequence complementarity to the regulated mRNA.

    • Maite Huarte
    Research Highlights
    Cell Research
    Volume: 23, P: 449-451