When carbon-based units are functionalized in photoredox catalysis, electrophilic coupling partners are often used, such that the polarities of the two fragments are appropriately matched. Here the authors show a generalized methodology to instead use nucleophilic coupling partners, which are cheaper and often simpler, via successive hydrogen atom transfer and oxidative radical-polar crossover.
- Isabelle Nathalie-Marie Leibler
- Makeda A. Tekle-Smith
- Abigail G. Doyle
