Nature Search

Global gridded dataset of heating and cooling degree days under climate change scenarios

Accurate projections of heating and cooling needs are vital for planning energy use and achieving the sustainable development goals. A global dataset now maps global heating and cooling degree days, finding future hotspots, rising cooling demand and early shifts in energy needs with major global impacts.

Jesus Lizana
Nicole D. Miranda
Malcolm McCulloch
Research26 Jan 2026
Nature Sustainability

P: 1-11
Coral calcification in a changing World and the interactive dynamics of pH and DIC upregulation

Coral reefs are biologically diverse and productive ecosystems, yet our understanding of the impacts of ocean acidification on biocalcification is limited. Here, the authors show that pH upregulation and the biological control of dissolved inorganic carbon in calcifying fluids ofPoritescorals are linked.

Malcolm T. McCulloch
Juan Pablo D’Olivo
Julie A. Trotter
ResearchOpen Access30 May 2017
Nature Communications

Volume: 8, P: 1-8
Embryology and Evolution

MALCOLM E. MACGREGOR
Research07 Feb 1931
Nature

Volume: 127, P: 200
Shallow-water sclerosponges on Jamaican reefs and a criterion for recognition of hurricane deposits

Terence P. Scoffin
Malcolm D. Hendry
Research23 Feb 1984
Nature

Volume: 307, P: 728-729
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Transcription of immunoglobulin heavy-chain sequences from the excluded allele

Phyllis A. Ponte
Miriam Siekevitz
Gail E. Sonenshein
Research18 Jun 1981
Nature

Volume: 291, P: 594-596
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
300 years of sclerosponge thermometry shows global warming has exceeded 1.5 °C

Understanding temperature change since the pre-industrial period is essential for climate action. This study uses an ocean proxy to better quantify when anthropogenic warming began and estimates that global temperatures have already increased by 1.7 °C.

Malcolm T. McCulloch
Amos Winter
Julie A. Trotter
ResearchOpen Access05 Feb 2024
Nature Climate Change

Volume: 14, P: 171-177
Change in cooling degree days with global mean temperature rise increasing from 1.5 °C to 2.0 °C

Failing to keep the increase of global mean temperature below 1.5 °C will have multiple negative implications. A study maps the annual changes in cooling demand, showing the most affected countries by warming, if the global mean temperature rises from 1.5 °C to 2.0 °C

Nicole D. Miranda
Jesus Lizana
Malcolm McCulloch
ResearchOpen Access13 Jul 2023
Nature Sustainability

Volume: 6, P: 1326-1330
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Author Correction: Stress-resistant corals may not acclimatize to ocean warming but maintain heat tolerance under cooler temperatures

Verena Schoepf
Steven A. Carrion
Malcolm T. McCulloch
Amendments and CorrectionsOpen Access04 Oct 2023
Nature Communications

Volume: 14, P: 1-2
Global warming and recurrent mass bleaching of corals

Aerial and underwater survey data combined with satellite-derived measurements of sea surface temperature over the past two decades show that multiple mass-bleaching events have expanded to encompass virtually all of the Great Barrier Reef.

Terry P. Hughes
James T. Kerry
Shaun K. Wilson
Research16 Mar 2017
Nature

Volume: 543, P: 373-377
Genetic mechanisms of critical illness in COVID-19

A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

Erola Pairo-Castineira
Sara Clohisey
J. Kenneth Baillie
Research11 Dec 2020
Nature

Volume: 591, P: 92-98
Coral record of increased sediment flux to the inner Great Barrier Reef since European settlement

Malcolm McCulloch
Stewart Fallon
David Barnes
Research13 Feb 2003
Nature

Volume: 421, P: 727-730
Coral resilience to ocean acidification and global warming through pH up-regulation

This study provides a quantitative approach that predicts the response of coral calcification to the combined effects of ocean acidification and global warming. The analysis suggests that warm-water aragonitic corals are more resilient to climate change than previously thought, whereas marine organisms that precipitate calcitic skeletons are particularly vulnerable.

Malcolm McCulloch
Jim Falter
Paolo Montagna
Research01 Apr 2012
Nature Climate Change

Volume: 2, P: 623-627
Stress-resistant corals may not acclimatize to ocean warming but maintain heat tolerance under cooler temperatures

Coral populations from thermally extreme conditions may help restore reefs degraded by bleaching. Here, the authors show that these corals can maintain their heat tolerance despite acclimation to colder temperatures but have a limited capacity to acclimatize to ocean warming.

Verena Schoepf
Steven A. Carrion
Malcolm T. McCulloch
ResearchOpen Access17 Sept 2019
Nature Communications

Volume: 10, P: 1-10
Seasonal characteristics of the Indian Ocean Dipole during the Holocene epoch

Nerilie J. Abram
Michael K. Gagan
Bambang W. Suwargadi
Research18 Jan 2007
Nature

Volume: 445, P: 299-302
Phasing and amplitude of sea-level and climate change during the penultimate interglacial

The penultimate interglacial period was punctuated by three sea-level highstands. Uranium–thorium ages obtained from speleothems in Italian caves show that the relationship between the timing of the peaks in sea level and Northern Hemisphere insolation is dependent on the previous extent of continental ice sheets.

Andrea Dutton
Edouard Bard
Malcolm T. McCulloch
Research06 Apr 2009
Nature Geoscience

Volume: 2, P: 355-359
Active modulation of the calcifying fluid carbonate chemistry (δ¹¹B, B/Ca) and seasonally invariant coral calcification at sub-tropical limits

Claire L. Ross
James L. Falter
Malcolm T. McCulloch
ResearchOpen Access23 Oct 2017
Scientific Reports

Volume: 7, P: 1-11
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Calcification trends in long-lived corals across the Indo-Pacific during the industrial era

Calcification rates of reef-building corals have decreased across the Indo-Pacific since 1900 due to recent marine heatwaves, according to analyses of coral core samples.

Thomas M. DeCarlo
Jordyn Cotton
Kathleen Matthews
ResearchOpen Access04 Dec 2024
Communications Earth & Environment

Volume: 5, P: 1-9
Coral calcification mechanisms in a warming ocean and the interactive effects of temperature and light

Corals show a heightened sensitivity to a combination of light and thermal stress after prolonged exposure to high ocean temperatures, according to four months-long mesocosm experiments that disentangle the effects of light and ocean warming.

Claire L. Ross
Andrew Warnes
Verena Schoepf
ResearchOpen Access30 Mar 2022
Communications Earth & Environment

Volume: 3, P: 1-11
Limits to the thermal tolerance of corals adapted to a highly fluctuating, naturally extreme temperature environment

Verena Schoepf
Michael Stat
Malcolm T. McCulloch
ResearchOpen Access02 Dec 2015
Scientific Reports

Volume: 5, P: 1-14
Cooling for sustainable development

Demand for cooling is expected to increase globally. To deliver sustainable cooling beyond energy-intensive technological solutions, a comprehensive analytical framework and research agenda are proposed.

Radhika Khosla
Nicole D. Miranda
Malcolm McCulloch
Reviews19 Oct 2020
Nature Sustainability

Volume: 4, P: 201-208
Marine heatwave causes unprecedented regional mass bleaching of thermally resistant corals in northwestern Australia

Morane Le Nohaïc
Claire L. Ross
Verena Schoepf
ResearchOpen Access03 Nov 2017
Scientific Reports

Volume: 7, P: 1-11

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