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Unique metabolic regulation of micromeres contributes to gastrulation in the sea urchin embryo

During sea urchin development, the micromeres form via asymmetric cell division and act as organizers to induce gastrulation. Here they show that micromeres have unique metabolic characteristics and that disrupting their metabolic activity blocks gastrulation induction.

Shakson Isaac
Douglas Dubosky
Mamiko Yajima
ResearchOpen Access11 Aug 2025
Nature Communications

Volume: 16, P: 1-18
Vasa nucleates asymmetric translation along the mitotic spindle during unequal cell divisions

Association of mRNA translation with the mitotic spindle is thought to be involved in localized production of cell fate determinants. Here, the authors show Vasa facilitates asymmetric translation, which contributes to differential regulation during sea urchin embryogenesis.

Ana Fernandez-Nicolas
Alicia Uchida
Mamiko Yajima
ResearchOpen Access20 Apr 2022
Nature Communications

Volume: 13, P: 1-15
The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells

DDX4, a conserved germline factor and RNA helicase, increases small cell lung cancer cell survival by regulating DNA damage and immune response pathways and contributes to cisplatin-mediated drug resistance.

Christopher Noyes
Shunsuke Kitajima
Mamiko Yajima
ResearchOpen Access18 Jan 2023
Communications Biology

Volume: 6, P: 1-14
Evolutionary modification of AGS protein contributes to formation of micromeres in sea urchins

Micromeres in a sea urchin embryo are formed by asymetric cleavage but what molecular mechanisms regulate their formation is unclear. Here, the authors show that sea urchins modify an evolutionarily conserved AGS-dependent mechanism to induce asymmetric cell divisions in the early embryo.

Jessica Poon
Annaliese Fries
Mamiko Yajima
ResearchOpen Access22 Aug 2019
Nature Communications

Volume: 10, P: 1-16
Sperm lacking Bindin are infertile but are otherwise indistinguishable from wildtype sperm

Gary M. Wessel
Yuuko Wada
Masato Kiyomoto
ResearchOpen Access03 Nov 2021
Scientific Reports

Volume: 11, P: 1-8
Genetic manipulation of the pigment pathway in a sea urchin reveals distinct lineage commitment prior to metamorphosis in the bilateral to radial body plan transition

Gary M. Wessel
Masato Kiyomoto
Mamiko Yajima
ResearchOpen Access06 Feb 2020
Scientific Reports

Volume: 10, P: 1-10

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Unique metabolic regulation of micromeres contributes to gastrulation in the sea urchin embryo

Vasa nucleates asymmetric translation along the mitotic spindle during unequal cell divisions

The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells

Evolutionary modification of AGS protein contributes to formation of micromeres in sea urchins

Sperm lacking Bindin are infertile but are otherwise indistinguishable from wildtype sperm

Genetic manipulation of the pigment pathway in a sea urchin reveals distinct lineage commitment prior to metamorphosis in the bilateral to radial body plan transition

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