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Brain-infiltrating CD4 T cells drive inflammatory microglia proliferation during cryptococcal meningitis in mice

Cryptococcal meningitis is a common infection in patients with compromised CD4 T cell function. Using a CD4 T cell activation tracking mouse the authors show the localisation and activation of CD4 T cells in the brain after cryptococcus infection and how these cells interact with MHCII expressing microglia which may increase pathologic brain inflammation.

Sofia Hain
Man Shun Fu
Rebecca A. Drummond
ResearchOpen Access09 Oct 2025
Nature Communications

Volume: 16, P: 1-19
Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

Jianxin Shi
Kouya Shiraishi
Qing Lan
ResearchOpen Access26 May 2023
Nature Communications

Volume: 14, P: 1-17
Diagnostic assessment of glaucoma and non-glaucomatous optic neuropathies via optical texture analysis of the retinal nerve fibre layer

Optical texture analysis of the retinal nerve fibre layer, via an algorithm integrating thickness and reflectance measurements from standard wide-field optical coherence tomography, outperforms conventional tomographic analysis in the detection of optic neuropathies.

Christopher Kai Shun Leung
Alexander Ka Ngai Lam
Gilda Wing Ki Lai
Research06 Jan 2022
Nature Biomedical Engineering

Volume: 6, P: 593-604
Microglia are not protective against cryptococcal meningitis

Cryptococcal meningitis is a life-threatening fungal infection. Here, Mohamed et al find that brain resident microglia do not provide protection against this infection and instead are a site where the fungus may access the micronutrient copper.

Sally H. Mohamed
Man Shun Fu
Rebecca A. Drummond
ResearchOpen Access08 Nov 2023
Nature Communications

Volume: 14, P: 1-15
Activation of the Notch1-c-myc-VCAM1 signalling axis initiates liver progenitor cell-driven hepatocarcinogenesis and pulmonary metastasis

Wen-Rui Wu
Xiang-De Shi
Chao Liu
Research07 Mar 2022
Oncogene

Volume: 41, P: 2340-2356

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Brain-infiltrating CD4 T cells drive inflammatory microglia proliferation during cryptococcal meningitis in mice

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Diagnostic assessment of glaucoma and non-glaucomatous optic neuropathies via optical texture analysis of the retinal nerve fibre layer

Microglia are not protective against cryptococcal meningitis

Activation of the Notch1-c-myc-VCAM1 signalling axis initiates liver progenitor cell-driven hepatocarcinogenesis and pulmonary metastasis

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