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Publisher Correction: Deep-learning-based virtual screening of antibacterial compounds

Gabriele Scalia
Steven T. Rutherford
Tommaso Biancalani
Amendments and Corrections07 Nov 2025
Nature Biotechnology

P: 1
Deep-learning-based virtual screening of antibacterial compounds

Antibacterial compounds are discovered by combining phenotypic screening with deep learning.

Gabriele Scalia
Steven T. Rutherford
Tommaso Biancalani
Research24 Oct 2025
Nature Biotechnology

P: 1-14
A microbiota-derived bile acid modulates biofilm formation by the probiotic strain Escherichia coli Nissle 1917

Elena K. Perry
Barath Udayasuryan
Man-Wah Tan
ResearchOpen Access04 Dec 2025
npj Biofilms and Microbiomes

Volume: 11, P: 1-20
The discovery and structural basis of two distinct state-dependent inhibitors of BamA

BamA carries out the essential process of folding outer membrane β-barrels in Gram-negative bacteria and is a potential antibiotic target. Here, the authors discover macrocyclic peptide inhibitors that trap BamA in distinct structural conformations.

Dawei Sun
Kelly M. Storek
Jian Payandeh
ResearchOpen Access08 Oct 2024
Nature Communications

Volume: 15, P: 1-15
Correction: Corrigendum: A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action

Ning Chai
Lee R. Swem
Man-Wah Tan
Amendments and CorrectionsOpen Access25 May 2017
Nature Communications

Volume: 8, P: 1-2
The aryl hydrocarbon receptor and FOS mediate cytotoxicity induced by Acinetobacter baumannii

In this work, authors study the proteins in uninfected and Acinetobacter baumannii infected human cells to understand how this bacterium causes disease.

Chun Kew
Cristian Prieto-Garcia
Ivan Dikic
ResearchOpen Access11 Sept 2024
Nature Communications

Volume: 15, P: 1-13
Neuroendocrine signals modulate the innate immunity of Caenorhabditis elegans through insulin signaling

In a variety of organisms, signals from the nervous system influence adaptive immunity. Tan and Kawli now show the importance of neuroendocrine inputs in the innate immunity of Caenorhabditis elegans to bacterial pathogens.

Trupti Kawli
Man-Wah Tan
Research14 Oct 2008
Nature Immunology

Volume: 9, P: 1415-1424
Alternative therapeutic strategies to treat antibiotic-resistant pathogens

In this Review, Tan and colleagues highlight recent efforts to discover non-traditional antimicrobials and explore the therapeutic potential of antimicrobial peptides and macrocycles, antibodies, bacteriophages and antisense-based therapeutics, focusing on how current research efforts are pushing these technologies towards clinical implementation.

Craig R. MacNair
Steven T. Rutherford
Man-Wah Tan
Reviews11 Dec 2023
Nature Reviews Microbiology

Volume: 22, P: 262-275
Optimized arylomycins are a new class of Gram-negative antibiotics

Chemical optimization of arylomycins results in an inhibitor of bacterial type I signal peptidase that shows activity both against multidrug-resistant clinical isolates of Gram-negative bacteria in vitro and in several in vivo infection models.

Peter A. Smith
Michael F. T. Koehler
Christopher E. Heise
Research12 Sept 2018
Nature

Volume: 561, P: 189-194
A Tet-Off gene expression system for validation of antifungal drug targets in a murine invasive pulmonary aspergillosis model

Yutian Peng
Hua Zhang
Man-Wah Tan
ResearchOpen Access11 Jan 2018
Scientific Reports

Volume: 8, P: 1-8
Publisher Correction: Definitions and guidelines for research on antibiotic persistence

Nathalie Q. Balaban
Sophie Helaine
Annelies Zinkernagel
Amendments and Corrections29 Apr 2019
Nature Reviews Microbiology

Volume: 17, P: 460
Structural basis for dual-mode inhibition of the ABC transporter MsbA

Crystal structures of the ABC transporter MsbA in complex with two selective small-molecule antagonists reveal an unprecedented allosteric mechanism of inhibition.

Hoangdung Ho
Anh Miu
Christopher M. Koth
Research02 May 2018
Nature

Volume: 557, P: 196-201
A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action

Influenza B virus (IBV) co-circulates with influenza A virus to cause annual epidemics. Here, Chaiet al. isolate a human monoclonal antibody that binds to a conserved epitope in the viral HA protein, neutralizes IBV strains in vitro, and protects mice against IBV infection.

Ning Chai
Lee R. Swem
Man-Wah Tan
ResearchOpen Access19 Jan 2017
Nature Communications

Volume: 8, P: 1-18
Outer membrane vesicles containing OmpA induce mitochondrial fragmentation to promote pathogenesis of Acinetobacter baumannii

Varnesh Tiku
Eric M. Kofoed
Man-Wah Tan
ResearchOpen Access12 Jan 2021
Scientific Reports

Volume: 11, P: 1-16
Definitions and guidelines for research on antibiotic persistence

Antibiotic persistence contributes to the survival of bacteria during antibiotic treatment. In this Consensus Statement, scientists working on the response of bacteria to antibiotics define antibiotic persistence and provide practical guidance on how to study bacterial persisters.

Nathalie Q. Balaban
Sophie Helaine
Annelies Zinkernagel
ReviewsOpen Access12 Apr 2019
Nature Reviews Microbiology

Volume: 17, P: 441-448

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Publisher Correction: Deep-learning-based virtual screening of antibacterial compounds

Deep-learning-based virtual screening of antibacterial compounds

A microbiota-derived bile acid modulates biofilm formation by the probiotic strain Escherichia coli Nissle 1917

The discovery and structural basis of two distinct state-dependent inhibitors of BamA

Correction: Corrigendum: A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action

The aryl hydrocarbon receptor and FOS mediate cytotoxicity induced by Acinetobacter baumannii

Neuroendocrine signals modulate the innate immunity of Caenorhabditis elegans through insulin signaling

Alternative therapeutic strategies to treat antibiotic-resistant pathogens

Optimized arylomycins are a new class of Gram-negative antibiotics

A Tet-Off gene expression system for validation of antifungal drug targets in a murine invasive pulmonary aspergillosis model

Publisher Correction: Definitions and guidelines for research on antibiotic persistence

Structural basis for dual-mode inhibition of the ABC transporter MsbA

A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action

Outer membrane vesicles containing OmpA induce mitochondrial fragmentation to promote pathogenesis of Acinetobacter baumannii

Definitions and guidelines for research on antibiotic persistence

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