NKX2-1 is the master transcription factor governing thyroid development and function. The authors used Nkx2-1(fl/fl);TPO-cre mice as a model to study in vivo regeneration and folliculogenesis of the thyroid. They found that NKX2-1 plays a role in differentiation through the modulation of the protein kinase AKT.
- Manabu Iwadate
- Yoshinori Takizawa
- Shioko Kimura