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Showing 1–2 of 2 results
Advanced filters: Author: Manami Harayama Clear advanced filters

  • Lipids are complex molecules crucial for life. The authors developed MS-DIAL 5, a tool that enhances in-depth structure elucidations and the spatial mapping of lipidome. Using advanced techniques, they uncovered new insights into the biosynthetic pathway of eye-specific phosphatidylcholines.

    • Hiroaki Takeda
    • Yuki Matsuzawa
    • Hiroshi Tsugawa
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Zinc ions (Zn2+) are imported by Golgi-resident transporters but the function of zinc in the early secretory pathway has remained unknown. Here the authors find that Zn2+ regulates protein quality control in the early secretory pathway by demonstrating that the pH-sensitive chaperone ERp44 binds Zn2+ and solving the Zn2+-bound ERp44 structure.

    • Satoshi Watanabe
    • Yuta Amagai
    • Kenji Inaba
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16