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Apolipoprotein-mediated pathways of lipid antigen presentation

Peter van den Elzen
Salil Garg
Michael B. Brenner
Research06 Oct 2005
Nature

Volume: 437, P: 906-910
Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors

Natural killer T (NKT) cells include type I that express semi-invariant T cell receptor (TCR), and type II that cover a broader repertoire. Here the authors describe the crystal structure of a type II NKT TCR complexed with CD1d/antigen to propose that type II NKT TCRs may adapt multiple CD1d docking modes to maximise antigen recognition efficacy.

Catarina F. Almeida
Srinivasan Sundararaj
Jamie Rossjohn
ResearchOpen Access20 Nov 2019
Nature Communications

Volume: 10, P: 1-14
Mechanism of CD1d-restricted natural killer T cell activation during microbial infection

Manfred Brigl
Lynn Bry
Michael B Brenner
Research26 Oct 2003
Nature Immunology

Volume: 4, P: 1230-1237
Lower TCR repertoire diversity in Traj18-deficient mice

Romain Bedel
Jennifer L Matsuda
Laurent Gapin
Correspondence19 Jul 2012
Nature Immunology

Volume: 13, P: 705-706
Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals

The identification of an endogenous ligand for natural killer T cells has remained elusive. Brenner and colleagues identify β-d-glucopyranosylceramide as a physiologically important self ligand for these cells.

Patrick J Brennan
Raju V V Tatituri
Michael B Brenner
Research30 Oct 2011
Nature Immunology

Volume: 12, P: 1202-1211
Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions

Invariant natural killer T (iNKT) cells are innate-like lymphocytes that express T cell receptors that can be activated by lipid antigens presented on CD1d molecules. Here, the authors describe different models of iNKT cell activation and discuss how activated iNKT cells can contribute to both protective and pathological immune responses.

Patrick J. Brennan
Manfred Brigl
Michael B. Brenner
Reviews21 Jan 2013
Nature Reviews Immunology

Volume: 13, P: 101-117
Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells

Using the Immunological Genome compendium, Brenner and colleagues shed light on the transcriptional programs that operate during the course of iNKT cell development and in peripheral CD4⁺ and CD4^– iNKT cell subsets.

Nadia R Cohen
Patrick J Brennan
Christophe Benoist
Research02 Dec 2012
Nature Immunology

Volume: 14, P: 90-99

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Apolipoprotein-mediated pathways of lipid antigen presentation

Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors

Mechanism of CD1d-restricted natural killer T cell activation during microbial infection

Lower TCR repertoire diversity in Traj18-deficient mice

Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals

Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions

Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells

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Apolipoprotein-mediated pathways of lipid antigen presentation

Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors

Mechanism of CD1d-restricted natural killer T cell activation during microbial infection

Lower TCR repertoire diversity in Traj18-deficient mice

Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals

Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions

Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells

Search

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